Gene: ARHGAP21
Official Full Name: Rho GTPase activating protein 21provided by HGNC
Gene Summary: ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO19722 | ARHGAP21 Knockout cell line (HeLa) | Human | ARHGAP21 | 1:3~1:6 | Negative | Online Inquiry |
KO19723 | ARHGAP21 Knockout cell line (HCT 116) | Human | ARHGAP21 | 1:2~1:4 | Negative | Online Inquiry |
KO19724 | ARHGAP21 Knockout cell line (HEK293) | Human | ARHGAP21 | 1:3~1:6 | Negative | Online Inquiry |
KO19725 | ARHGAP21 Knockout cell line (A549) | Human | ARHGAP21 | 1:3~1:4 | Negative | Online Inquiry |
ARHGAP21 Gene Knockout Cell Lines are specialized cellular models in which the ARHGAP21 gene has been inactivated through targeted genome editing techniques. This product is critically designed for researchers to investigate the biological functions of the ARHGAP21 protein, which plays a vital role in cellular signaling pathways, cytoskeletal organization, and potentially in various pathologies including cancer. By using these knockout cell lines, scientists can elucidate the specific functions of ARHGAP21 by observing the phenotypic and molecular changes that occur in the absence of this gene.
The key mechanism behind the utility of ARHGAP21 Gene Knockout Cell Lines lies in their ability to provide a controlled environment for studying gene function and associated cellular processes. These cell lines allow for the in-depth exploration of ARHGAP21's role in modulating actin dynamics and its impact on cell motility and morphology. This, in turn, can shed light on ARHGAP21's involvement in tumor progression and metastasis, making them a valuable tool in both basic and applied research.
The scientific importance of ARHGAP21 Gene Knockout Cell Lines extends into numerous research fields, including cancer biology, developmental biology, and neurobiology. Their application in preclinical studies can help in assessing therapeutic targets or biomarkers associated with various diseases. Furthermore, these cell lines can serve as platforms to develop innovative treatments and study resistance mechanisms in oncological therapies.
One of the unique selling points of ARHGAP21 Gene Knockout Cell Lines is their high specificity and reproducibility, achieved through advanced CRISPR/Cas9 gene-editing technology. Unlike conventional cell models, these knockout lines minimize off-target effects, allowing for more accurate interpretations of experimental results. Additionally, they are tailored to meet stringent quality controls, ensuring that they provide reliable data for critical research applications.
Researchers and clinicians seeking to unravel the complexities of cellular signaling and its implications in disease will find immense value in ARHGAP21 Gene Knockout Cell Lines. This product not only offers a precise model for fundamental research but also supports translational applications aimed at developing new therapeutic strategies.
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Please note that all services are for research use only. Not intended for any clinical use.
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