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ARF1 Knockout Cell Lines

Gene: ARF1

Official Full Name: ARF GTPase 1provided by HGNC

Gene Summary: ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07750 ARF1 Knockout cell line (HeLa) Human ARF1 1:3~1:6 Negative Online Inquiry
KO07751 ARF1 Knockout cell line (HCT 116) Human ARF1 1:2~1:4 Negative Online Inquiry
KO07752 ARF1 Knockout cell line (HEK293) Human ARF1 1:3~1:6 Negative Online Inquiry
KO07753 ARF1 Knockout cell line (A549) Human ARF1 1:3~1:4 Negative Online Inquiry

Background

ARF1 Gene Knockout Cell Lines are precisely engineered cellular models that lack the ARF1 gene, which encodes a member of the ADP-ribosylation factor (ARF) family involved in diverse cellular functions, including vesicular trafficking and cellular signaling. These knockout cell lines serve as invaluable tools for researchers investigating the role of ARF1 in various biological processes and disease states. By disabling this gene, scientists can uncover the specific mechanisms through which ARF1 influences cellular dynamics, allowing for a more comprehensive understanding of its role in health and disease.

The primary function of ARF1 includes regulating membrane traffic, signaling pathways, and lipid metabolism. Its knockout results in alterations to intracellular transport processes, which can be utilized to explore pathways relevant to cancer, neurodegeneration, and metabolic diseases. In research settings, utilizing ARF1 Gene Knockout Cell Lines permits the dissection of functional pathways primarily attributable to ARF1, paving the way for novel therapeutic strategies and hypothesis testing.

In clinical applications, these cell lines can be employed as models for drug discovery and development, particularly for treatments targeting vesicular transport-related disorders. The unique advantage of the ARF1 knockout models lies in their ability to mimic specific pathophysiological conditions more closely than traditional models, offering a higher fidelity for translational research.

This product stands out from alternative offerings by providing a complete knockout system, which ensures that the intrinsic functions of ARF1 can be meticulously studied without compensatory mechanisms that may otherwise cloud experimental results. Researchers and clinicians benefit from this specificity, as it enhances the reliability of findings and accelerates the pathway from bench to bedside.

Our company specializes in generating high-quality biological products and cellular models, with a commitment to advancing scientific knowledge and facilitating groundbreaking research. The ARF1 Gene Knockout Cell Lines exemplify our dedication to supporting researchers and clinicians in their quest to elucidate the complexities of gene function and its implications in human health.

Please note that all services are for research use only. Not intended for any clinical use.

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