Gene: AOC3
Official Full Name: amine oxidase copper containing 3provided by HGNC
Gene Summary: This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33981 | AOC3 Knockout cell line (HCT 116) | Human | AOC3 | 1:2~1:4 | Negative | Online Inquiry |
KO33982 | AOC3 Knockout cell line (HEK293) | Human | AOC3 | 1:3~1:6 | Negative | Online Inquiry |
KO33983 | AOC3 Knockout cell line (A549) | Human | AOC3 | 1:3~1:4 | Negative | Online Inquiry |
AOC3 Gene Knockout Cell Lines are genetically engineered cellular models designed to facilitate the investigation of the amine oxidase, copper containing 3 (AOC3) gene function and its implications in various biological processes. This product consists of established cell lines in which the AOC3 gene has been completely inactivated, allowing researchers to study the downstream effects of AOC3 deficiency on cellular and physiological pathways.
The primary function of these knockout cell lines is to provide a stable platform for examining the roles of AOC3 in processes such as neurotransmitter metabolism, vascular homeostasis, and oxidative stress responses. By utilizing CRISPR-Cas9 technology, these cell lines demonstrate enhanced precision and reliability in gene disruption, granting researchers a robust tool for elucidating the molecular mechanisms underlying a wide range of diseases, including cardiovascular disorders and neurodegenerative diseases.
In terms of scientific importance, AOC3 Gene Knockout Cell Lines serve as vital tools in both basic and applied research settings. Investigators can explore gene functions within physiologically relevant contexts, validate drug targets, and assess the efficacy of therapeutic compounds aimed at modulating AOC3 activity. The ability to understand the precise contributions of AOC3 to pathophysiological processes opens avenues for novel treatment strategies.
Compared to alternative models that may not fully capture the complexities of gene interactions, these knockout cell lines offer superior specificity and sensitivity. Researchers can avoid the confounding effects observed in heterozygous or wild-type cell lines and gain clearer insights into the consequences of AOC3 loss-of-function. The consistent expression profiles and reproducibility of experimental outcomes significantly enhance data integrity.
For researchers, clinicians, and pharmaceutical companies, AOC3 Gene Knockout Cell Lines represent a resource that accelerates discovery and innovation in the field of genomics and drug development. The validated, high-quality nature of these cell lines ensures that users can trust the results of their experiments and drive forward their scientific objectives with confidence.
Our company specializes in providing cutting-edge biological products and pre-engineered cellular models designed to empower the scientific community. With a commitment to quality and innovation, we offer unparalleled support and expertise, ensuring users maximize the potential of their research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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