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ANXA8 Knockout Cell Lines

Gene: ANXA8

Official Full Name: annexin A8provided by HGNC

Gene Summary: This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO19787 ANXA8 Knockout cell line (HeLa) Human ANXA8 1:3~1:6 Negative Online Inquiry
KO19788 ANXA8 Knockout cell line (A549) Human ANXA8 1:3~1:4 Negative Online Inquiry

Background

ANXA8 Gene Knockout Cell Lines are sophisticated biological tools designed to elucidate the functional roles of the ANXA8 gene, which encodes the Annexin A8 protein. This protein is known for its involvement in diverse cellular processes, including membrane dynamics, cell signaling, and inflammation response. By creating knockout cell lines, researchers can effectively study the loss-of-function effects on cellular behavior, signaling pathways, and disease states, particularly in the contexts of cancer and neurodegenerative disorders.

The key mechanism behind these knockout cell lines involves the targeted deletion of the ANXA8 gene, typically achieved through CRISPR-Cas9 technology. This precise genomic editing allows for the generation of cell lines where ANXA8 is completely absent, providing invaluable models for investigating the protein's contribution to various physiological and pathological processes. The ability to observe the resulting phenotypic changes facilitates insights into cellular mechanisms, drug responses, and the potential for novel therapeutic strategies.

The scientific importance of ANXA8 Gene Knockout Cell Lines extends beyond basic research; they have significant applications in translational medicine, enabling the identification of potential biomarkers and therapeutic targets. In clinical settings, understanding how the absence of Annexin A8 influences tumor behavior or neurodegeneration could lead to breakthroughs in targeted therapies or preventive strategies.

What sets our ANXA8 Gene Knockout Cell Lines apart from alternatives is the guarantee of high efficiency and specificity in gene disruption, coupled with comprehensive validation for consistent performance. These cell lines are meticulously characterized to ensure reproducibility, making them a reliable choice for both academic and industrial research settings.

Researchers and clinicians alike will find great value in our ANXA8 Gene Knockout Cell Lines as they provide a critical resource for dissecting the gene's biological roles and contributing to advancements in therapeutic development. With years of expertise in cellular biology and genomic technologies, our company is dedicated to offering precise and innovative products that empower discoveries in life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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