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ANO9 Knockout Cell Lines

Gene: ANO9

Official Full Name: anoctamin 9provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the TMEM16 (anoctamin) family of proteins, some of which form integral membrane calcium-activated chloride channels. The function of the encoded protein has yet to be elucidated, although it may have channel-forming abilities and also may have phospholipid scramblase activity. This gene has been observed to be upregulated in stage II and III colorectal cancers. [provided by RefSeq, Dec 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO19796 ANO9 Knockout cell line (HCT 116) Human ANO9 1:2~1:4 Negative Online Inquiry

Background

ANO9 Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the ANO9 gene, which encodes for a member of the anoctamin family of calcium-activated chloride channels. These cell lines serve as essential tools for investigating the physiological roles of ANO9 in various biological processes, including cell signaling, ion transport, and developmental biology. By eliminating the ANO9 gene, researchers can delineate its contributions to cellular functions and the pathophysiological mechanisms underlying diseases such as cancer and cystic fibrosis.

The ANO9 gene knockout operates through techniques such as CRISPR-Cas9 gene editing, which ensures precise targeting and deletion of the gene. This mechanism allows scientists to explore the effects of ANO9 absence on cellular morphology, proliferation, and ion homeostasis. As such, these cell lines are invaluable for functional studies and for screening potential therapeutic compounds that might target ANO9-related pathways.

The scientific importance of ANO9 Gene Knockout Cell Lines extends into both research and clinical settings. In research, these models enable investigators to explore the fundamental biology of chloride channels and their roles in human diseases. Clinically, findings derived from studies using ANO9 knockout cell lines can lead to novel therapeutic approaches that harness the insights gained from the disrupted gene function.

An important advantage of using our ANO9 Gene Knockout Cell Lines is their validation and consistency in experimental results, which significantly reduces variability often encountered in biological systems. Furthermore, these cell lines are readily available and easy to use, making them ideal for both routine experiments and high-throughput screening applications.

For researchers and clinicians seeking to deepen their understanding of chloride channels and their related pathways, the ANO9 Gene Knockout Cell Lines offer a unique opportunity to obtain reliable data that can accelerate scientific discovery and potentially lead to innovative treatment strategies. Our company prides itself on its commitment to providing high-quality products, backed by years of expertise in genetic engineering and cell line development, ensuring that you have the best tools available to enhance your research efforts.

Please note that all services are for research use only. Not intended for any clinical use.

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