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ANKRD6 Knockout Cell Lines

Gene: ANKRD6

Official Full Name: ankyrin repeat domain 6provided by HGNC

Gene Summary: Predicted to be involved in negative regulation of canonical Wnt signaling pathway and positive regulation of JNK cascade. Predicted to act upstream of or within positive regulation of Wnt signaling pathway, planar cell polarity pathway. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30181 ANKRD6 Knockout cell line (HCT 116) Human ANKRD6 1:2~1:4 Negative Online Inquiry
KO30182 ANKRD6 Knockout cell line (HEK293) Human ANKRD6 1:3~1:6 Negative Online Inquiry
KO30183 ANKRD6 Knockout cell line (A549) Human ANKRD6 1:3~1:4 Negative Online Inquiry

Background

ANKRD6 Gene Knockout Cell Lines are genetically modified cell models designed to specifically disrupt the ANKRD6 gene, which plays a crucial role in various cellular processes, including cell growth, differentiation, and response to stress signals. By using CRISPR-Cas9 technology, these cell lines are engineered to create a precise knockout, allowing researchers to explore the biological implications of ANKRD6 depletion in both in vitro and in vivo contexts.

The primary function of ANKRD6 gene knockout cell lines is to facilitate the study of gene function and the associated pathways. The knockout mechanism leads to the absence of the ANKRD6 protein, which can significantly alter cellular behavior and gene expression profiles. This alteration allows researchers to investigate how ANKRD6 influences biological processes, including tumorigenesis, apoptosis, and immune responses, providing crucial insights into its role in health and disease.

The scientific importance of ANKRD6 knockout cell lines is underscored by their diverse applications in research and clinical settings. They serve as valuable tools for drug discovery, genetic research, and biomarker identification, particularly in cancer biology, where ANKRD6 has been implicated in tumor progression and metastasis. Furthermore, the ability to observe phenotypic changes resulting from the knockout can lead to potential therapeutic targets and inform treatment strategies.

Compared to traditional methods such as RNA interference (RNAi) or other gene editing tools, ANKRD6 gene knockout cell lines provide enhanced specificity and permanent alterations in gene expression. This advantage ensures that the observed effects are directly related to the absence of the ANKRD6 protein, eliminating confounding factors that can arise with transient transient knockdown approaches.

For researchers, clinicians, and developers, the value of ANKRD6 gene knockout cell lines lies in their potential to uncover new therapeutic avenues and deepen our understanding of complex genetic interactions. These cell lines empower the scientific community to drive innovations that may translate into clinical applications benefiting patients.

Our company prides itself on offering high-quality, validated biological products, and our expertise in genetics and cell biology ensures that researchers have access to tools that meet rigorous scientific standards. Our commitment to innovation and excellence empowers our customers to advance their research and make impactful discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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