Gene: ALPP
Official Full Name: alkaline phosphatase, placentalprovided by HGNC
Gene Summary: The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. One of the main sources of this enzyme is the liver, and thus, it's one of several indicators of liver injury in different clinical conditions. In pregnant women, this protein is primarily expressed in placental and endometrial tissue, however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Aug 2020]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04604 | ALPP Knockout cell line (HeLa) | Human | ALPP | 1:3~1:6 | Negative | Online Inquiry |
ALPP Gene Knockout Cell Lines are genetically engineered cellular models designed to lack the ALPP gene (alkaline phosphatase, placental-type), enabling researchers to investigate the role of this gene in various biological processes and diseases. By utilizing CRISPR-Cas9 technology, these cell lines exhibit precisely targeted disruptions, allowing for unambiguous analysis of gene function, cellular pathways, and potential compensatory mechanisms in pathological conditions.
The key function of ALPP Gene Knockout Cell Lines is to facilitate the study of ALPP-mediated signaling pathways. The absence of the ALPP gene in these models enables researchers to assess its contribution to processes such as cellular differentiation, metabolism, and tissue homeostasis. By elucidating the gene's biological functions, scientists are better equipped to understand its implications in conditions like cancer, neurodegenerative disorders, and skeletal diseases.
From a scientific perspective, the applications of ALPP Gene Knockout Cell Lines in research and clinical settings are profound. They serve as vital tools for drug discovery, biomarker identification, and the exploration of new therapeutic targets. Investigating ALPP's role could unlock new pathways for treatment in diseases where dysregulation of alkaline phosphatase plays a pivotal role.
The unique advantage of ALPP Gene Knockout Cell Lines lies in their specificity and reproducibility when compared to traditional cell models or non-targeted gene disruption methods. These cell lines expedite research timelines and enhance the reliability of experimental data, which are critical attributes in the competitive landscape of biomedicine.
Researchers, clinicians, and pharmaceutical companies will find exceptional value in ALPP Gene Knockout Cell Lines due to their precision in modeling diseases related to ALPP deficiency. Their effectiveness in providing clear insights into gene function supports innovative research, ultimately leading to improved patient outcomes.
Our company specializes in the development of state-of-the-art biological tools, drawing on extensive expertise in genetic engineering and cell biology. By offering highly characterized and validated cell lines, we empower scientific discovery, fostering advancements in both research and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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