Gene: AGFG1
Official Full Name: ArfGAP with FG repeats 1provided by HGNC
Gene Summary: The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. The encoded protein binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37203 | AGFG1 Knockout cell line (HeLa) | Human | AGFG1 | 1:3~1:6 | Negative | Online Inquiry |
KO37204 | AGFG1 Knockout cell line (HCT 116) | Human | AGFG1 | 1:2~1:4 | Negative | Online Inquiry |
KO37205 | AGFG1 Knockout cell line (HEK293) | Human | AGFG1 | 1:3~1:6 | Negative | Online Inquiry |
KO37206 | AGFG1 Knockout cell line (A549) | Human | AGFG1 | 1:3~1:4 | Negative | Online Inquiry |
AGFG1 Gene Knockout Cell Lines are genetically engineered cell lines in which the AGFG1 gene has been purposely disrupted or "knocked out." This crucial tool in molecular biology allows researchers to investigate the specific functions of the AGFG1 protein, which is involved in intracellular transport processes and is linked to various cellular activities, including cell proliferation and signaling pathways.
The mechanisms by which AGFG1 Gene Knockout Cell Lines function hinge on the targeted deletion of the AGFG1 gene, typically achieved using CRISPR-Cas9 technology. This gene-editing approach enables precise modifications at the genomic level, resulting in the complete absence of AGFG1 protein expression. Researchers can utilize these knockout models to elucidate the role of AGFG1 in physiological and pathological contexts, thereby offering insights into disease mechanisms and potential therapeutic targets.
Scientific importance in both research and clinical settings is paramount, as AGFG1 is associated with various cellular disorders, including cancer and neurodegenerative diseases. Understanding the pathways and interactions involving AGFG1 can lead to the development of innovative treatment strategies or diagnostics, significantly impacting patient care.
Compared to alternative approaches for studying gene function, such as RNA interference or overexpression models, AGFG1 Gene Knockout Cell Lines provide a more definitive analysis of gene loss. This clear delineation of gene function is crucial for data interpretation and subsequent experimental designs. Moreover, these cell lines are meticulously validated and optimized for a range of experimental techniques, making them versatile tools for a variety of research applications.
For researchers and clinicians aiming to deepen the understanding of AGFG1's role in disease and biology, AGFG1 Gene Knockout Cell Lines provide a reliable and effective means to generate valuable data. Our company specializes in high-quality biological products, ensuring that customers have access to essential tools that empower their research endeavors and clinical applications. With years of expertise in genetic engineering, our offerings are optimized for performance and reproducibility, supporting a commitment to advancing science.
Please note that all services are for research use only. Not intended for any clinical use.
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