Gene: ADPRHL1
Official Full Name: ADP-ribosylhydrolase like 1provided by HGNC
Gene Summary: ADP-ribosylation is a reversible posttranslational modification used to regulate protein function. ADP-ribosyltransferases (see ART1; MIM 601625) transfer ADP-ribose from NAD+ to the target protein, and ADP-ribosylhydrolases, such as ADPRHL1, reverse the reaction (Glowacki et al., 2002 [PubMed 12070318]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO30826 | ADPRHL1 Knockout cell line (HeLa) | Human | ADPRHL1 | 1:3~1:6 | Negative | Online Inquiry |
KO30827 | ADPRHL1 Knockout cell line (HCT 116) | Human | ADPRHL1 | 1:2~1:4 | Negative | Online Inquiry |
KO30828 | ADPRHL1 Knockout cell line (HEK293) | Human | ADPRHL1 | 1:3~1:6 | Negative | Online Inquiry |
KO30829 | ADPRHL1 Knockout cell line (A549) | Human | ADPRHL1 | 1:3~1:4 | Negative | Online Inquiry |
ADPRHL1 Gene Knockout Cell Lines are genetically modified cell lines characterized by the targeted disruption of the ADPRHL1 gene, which encodes the enzyme ADP-ribosylhydrolase 1. This specialized product is crucial for researchers focusing on the role of ADPRHL1 in cellular processes such as DNA repair, cell death, and inflammation, among others. By employing CRISPR/Cas9 technology, these cell lines exhibit a complete knockout of the ADPRHL1 gene, allowing for the precise examination of its biological functions and contributions to pathophysiological conditions.
The key function of ADPRHL1 involves regulating cellular responses to stress and modulating the ADP-ribosylation signaling pathway. Research has shown that ADPRHL1 plays a vital role in maintaining cellular homeostasis, and its dysfunction is often linked to various diseases, including cancer and neurodegeneration. Utilizing these knockout cell lines facilitates the study of ADPRHL1's involvement in these pathways, offering insights into potential therapeutic interventions and drug development.
The scientific importance of ADPRHL1 Gene Knockout Cell Lines extends to both basic and applied research settings. In the laboratory, they serve as a powerful platform for investigating gene function, genetic interactions, and the effects of targeted therapies. Moreover, their use in clinical research can lead to the identification of biomarkers or therapeutic targets for conditions associated with ADPRHL1 dysregulation.
Compared to alternative products, the ADPRHL1 Gene Knockout Cell Lines provide a unique advantage by offering a complete and reliable interruption of the target gene, ensuring the reproducibility and consistency of experimental outcomes. Such precision is vital in the elucidation of gene functions, making these cell lines an indispensable tool in modern molecular biology research.
Researchers and clinicians will find value in the utility of these knockout lines to enhance their understanding of complex biological systems and identify novel therapeutic strategies. Our company, with its commitment to providing high-quality genetic tools and technologies, stands ready to support your research endeavors with the best in biological products, including the advanced ADPRHL1 Gene Knockout Cell Lines.
Please note that all services are for research use only. Not intended for any clinical use.
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