Gene: ADGRE1
Official Full Name: adhesion G protein-coupled receptor E1provided by HGNC
Gene Summary: This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO06882 | ADGRE1 Knockout cell line (A549) | Human | ADGRE1 | 1:3~1:4 | Negative | Online Inquiry |
ADGRE1 Gene Knockout Cell Lines are genetically engineered cellular models designed to lack the expression of the ADGRE1 gene, also known as the adhesion G protein-coupled receptor E1. This product serves as a powerful tool for researchers studying the intricate roles of ADGRE1 in various biological processes, including cell adhesion, migration, and immune responses. The knockout mechanism employed allows for the precise elimination of ADGRE1’s functionality, providing a clear framework to investigate the downstream effects and physiological implications of its absence.
The key functions of ADGRE1 include its involvement in mediating cellular signaling pathways critical for immune cell activation and tissue homeostasis. By utilizing these knockout cell lines, researchers can explore changes in cellular behavior and signaling networks that stem from the loss of ADGRE1. This ability to dissect complex biological interactions enhances the understanding of various diseases, including cancer and autoimmune disorders, where ADGRE1 may play a contributing role.
The scientific importance of ADGRE1 Gene Knockout Cell Lines extends to both research and clinical applications. In laboratory settings, these models allow for the identification of potential therapeutic targets and the evaluation of novel treatments aimed at modulating immune responses. In clinical research, understanding ADGRE1’s role could lead to advancements in personalized medicine, where tailored therapies could be developed based on individual patient profiles.
Compared to alternatives such as transient knockdown methods, ADGRE1 Gene Knockout Cell Lines provide more stable and reproducible results, facilitating long-term studies on ADGRE1 function. The ability to conduct experiments over extended periods without the variable expression levels associated with transient techniques enhances the reliability of the findings.
Researchers and clinicians alike will find immense value in these knockout cell lines, as they enable comprehensive investigations into ADGRE1-mediated processes, potentially leading to significant breakthroughs in therapeutic development and disease understanding. Our company prides itself on delivering high-quality biological products, backed by extensive expertise in genetic engineering and cell line development, ensuring that our ADGRE1 Gene Knockout Cell Lines meet the rigorous standards demanded by the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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