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ADD2 Knockout Cell Lines

Gene: ADD2

Official Full Name: adducin 2provided by HGNC

Gene Summary: Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO39104 ADD2 Knockout cell line (HEK293) Human ADD2 1:3~1:6 Negative Online Inquiry
KO39105 ADD2 Knockout cell line (A549) Human ADD2 1:3~1:4 Negative Online Inquiry

Background

ADD2 Gene Knockout Cell Lines are genetically engineered mammalian cell lines where the ADD2 gene has been specifically inactivated using advanced CRISPR/Cas9 technology. This strategically designed knockout allows for the precise exploration of the gene’s functions and implications in cellular processes such as cytoskeletal organization, cell signaling, and membrane integrity. By removing the ADD2 gene, researchers can study the resultant phenotypic changes and potentially elucidate its role in relevant biological systems that contribute to various diseases, particularly those affecting the musculoskeletal system.

The ADD2 gene plays a critical role in the regulation of the cytoskeleton and cell adhesive interactions, making its knockout significant for understanding cellular mechanisms of disease and development. These cell lines enable researchers to investigate the underlying molecular pathways influenced by ADD2, fostering advancements in targeted therapies for disorders associated with cytoskeletal dysfunction.

What sets ADD2 Gene Knockout Cell Lines apart from alternatives is their unparalleled specificity and reliability. Each cell line is validated for CRISPR efficiency and gene editing precision, ensuring that researchers are working with a product that adheres to the highest standards of genomic integrity. Additionally, these cell lines come with extensive supporting documentation, including proof of gene knockout efficiency, which is essential for experimental reproducibility and reliability.

Researchers and clinicians alike will find these cell lines to be invaluable resources in their quest for innovative treatments and deeper biological insights. The ability to manipulate genetic expression with accuracy and ease accelerates exploratory science and therapeutic development, making them a vital tool for academic and pharmaceutical research settings.

With a commitment to pioneering high-quality biological products, our company leverages years of expertise in genetic engineering and cell biology to offer researchers reliable and innovative solutions, positioning them at the forefront of scientific discovery and clinical advancement.

Please note that all services are for research use only. Not intended for any clinical use.

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