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ADAL Knockout Cell Lines

Gene: ADAL

Official Full Name: N6-Methyl-AMP deaminaseprovided by HGNC

Gene Summary: Predicted to enable adenosine deaminase activity. Predicted to be involved in adenosine catabolic process and inosine biosynthetic process. Predicted to act upstream of or within response to alcohol. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20009 ADAL Knockout cell line (HeLa) Human ADAL 1:3~1:6 Negative Online Inquiry
KO20010 ADAL Knockout cell line (HCT 116) Human ADAL 1:2~1:4 Negative Online Inquiry
KO20011 ADAL Knockout cell line (HEK293) Human ADAL 1:3~1:6 Negative Online Inquiry
KO20012 ADAL Knockout cell line (A549) Human ADAL 1:3~1:4 Negative Online Inquiry

Background

ADAL Gene Knockout Cell Lines comprise a collection of genetically engineered cell lines designed to specifically disrupt the expression of the adenosine deaminase-like (ADAL) gene. This product is fundamental for researchers focused on elucidating the role of ADAL in biological pathways, including but not limited to, immune responses, cellular proliferation, and metabolic regulation. By employing CRISPR-Cas9 genome-editing technology, these knockout cell lines allow for precise ablation of the ADAL gene, facilitating the investigation of its functions in various biological contexts.

The primary mechanism through which ADAL Gene Knockout Cell Lines function is by providing a model system in which the typically expressed ADAL protein is absent. This absence can unveil critical insights into the contributions of ADAL to cellular behaviors and physiological processes, thereby enabling researchers to identify downstream effects and potential compensatory pathways. Scientists can utilize these knockout lines to explore mechanisms of disease linked to ADAL dysregulation, making them invaluable for both basic research and translational applications.

The scientific importance of these cell lines cannot be overstated, as they open up avenues for drug discovery and the development of therapeutic interventions that target ADAL-related pathways. Studies leveraging these knockout models are particularly relevant in the fields of immunology and oncology, where understanding the nuanced role of adenosine metabolism can illuminate novel therapeutic strategies.

Compared to conventional methods of gene disruption, ADAL Gene Knockout Cell Lines offer enhanced reliability and specificity. While traditional RNA interference and chemical inhibitors may exhibit off-target effects, the precision of CRISPR technology ensures a clean knockout, making results more interpretable and reproducible. These cell lines are also compatible with high-throughput screening formats, promoting efficiency in research workflows.

Researchers and clinicians will find ADAL Gene Knockout Cell Lines to be an indispensable resource for advancing their studies. By providing unique insights into gene function, these cell lines empower scientific innovation and contribute to the development of therapies that can elevate patient care.

Our company prides itself on delivering cutting-edge biological products backed by rigorous scientific validation and an experienced team of experts in genomic technologies. The ADAL Gene Knockout Cell Lines exemplify our commitment to supporting the scientific community through reliable and robust solutions.

Please note that all services are for research use only. Not intended for any clinical use.

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