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ACTC1 Knockout Cell Lines

Gene: ACTC1

Official Full Name: actin alpha cardiac muscle 1provided by HGNC

Gene Summary: Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01814 ACTC1 Knockout cell line (HeLa) Human ACTC1 1:3~1:6 Negative Online Inquiry

Background

ACTC1 Gene Knockout Cell Lines are specialized cell models engineered to lack the expression of the ACTC1 gene, which encodes for cardiac actin, a crucial protein involved in the structure and functionality of muscle fibers in the heart. This product is created using state-of-the-art CRISPR/Cas9 gene-editing technology, enabling precise modification of the genomic sequence to achieve the desired knockout phenotype. By eliminating the ACTC1 gene, these cell lines serve as an invaluable tool for researchers investigating the fundamental role of cardiac actin in cellular processes and heart biology.

The primary function of ACTC1 Gene Knockout Cell Lines lies in their ability to provide insight into the physiological and pathological mechanisms underlying cardiac function and diseases such as cardiomyopathy. Researchers can manipulate these cells to study the effects of the absence of ACTC1 on cardiac muscle contractility, signal transduction pathways, and structural integrity of cardiac tissues. These models are a powerful resource for gene function studies, drug screening, and the development of gene therapies.

From a scientific perspective, ACTC1 Gene Knockout Cell Lines hold immense value in translational research, bridging the gap between in vitro studies and clinical applications. They are particularly advantageous for cardiac biomedical research, providing a framework for understanding genetic defects leading to heart disease. Unlike traditional cell lines, which may retain incomplete gene expression profiles, these knockout models offer a clean slate that empowers researchers to analyze specific cellular responses without confounding factors.

One of the standout advantages of our ACTC1 Gene Knockout Cell Lines is their unparalleled specificity and reliability, ensuring reproducibility in experimental results. These cell lines come with a robust background of characterization, offering researchers confidence in their usage for various applications. Furthermore, they are compatible with a wide range of experimental protocols, including high-throughput screening, proteomic studies, and time-lapse imaging, ensuring versatility in research designs.

In conclusion, ACTC1 Gene Knockout Cell Lines are essential for advancing our understanding of cardiac biology and developing innovative therapeutic strategies. As an organization, we pride ourselves on our expertise in genetic engineering and commitment to providing high-quality biological tools that facilitate groundbreaking research. Our product offering is designed to empower researchers and clinicians in their quest to unravel the complexities of heart disease and achieve transformative outcomes in patient care.

Please note that all services are for research use only. Not intended for any clinical use.

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