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ACSS3 Knockout Cell Lines

Gene: ACSS3

Official Full Name: acyl-CoA synthetase short chain family member 3provided by HGNC

Gene Summary: Enables propionate-CoA ligase activity. Predicted to be involved in ketone body biosynthetic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00430 ACSS3 gRNA5-gRNA6 KO plasmid ACSS3 $850
KO00715 ACSS3 Knockout cell line(A549) Human ACSS3 1:3~1:4 Negative Online Inquiry
KO20026 ACSS3 Knockout cell line (HEK293) Human ACSS3 1:3~1:6 Negative Online Inquiry

Background

ACSS3 Gene Knockout Cell Lines are specially engineered cellular models that enable the functional study of the acyl-CoA synthetase short-chain family member 3 (ACSS3) gene. By creating knockout lines, where the ACSS3 gene is selectively inactivated, researchers can investigate the gene's role in various biological processes, including fatty acid metabolism, cellular energy homeostasis, and responses to metabolic stress. This product harnesses CRISPR-Cas9 technology to ensure precise gene editing, leading to reproducible and reliable biological outcomes.

The primary function of ACSS3 is to activate acetate into acyl-coenzyme A, which is critical in metabolic pathways that govern energy production and lipid synthesis. By utilizing these knockout cell lines, researchers can discern the cellular effects and metabolic repercussions that stem from the absence of ACSS3, offering insights into its function in health and disease states, including cancer metabolism, cardiovascular diseases, and metabolic syndromes.

The importance of ACSS3 Gene Knockout Cell Lines stretches across both research and clinical settings. They provide invaluable tools for pharmacological studies, enabling scientists to screen for drugs that may target these metabolic pathways. Furthermore, these cell lines can be used in gene therapy research and for studying gene-environment interactions that impact human health.

ACSS3 Gene Knockout Cell Lines offer distinct advantages over traditional methods of studying gene function, such as whole-organism models or temporary knockdowns that may not provide consistent results. The permanent gene knockout allows for long-term studies, ensuring that phenotypic changes can be observed under various conditions. Additionally, because of the specificity of the CRISPR technology employed in their creation, these cell lines exhibit minimal off-target effects, enhancing confidence in experimental outcomes.

For researchers and clinicians focused on understanding metabolic diseases and developing innovative therapeutic strategies, these knockout cell lines provide a crucial resource. By utilizing our ACSS3 Gene Knockout Cell Lines, you engage with a product backed by cutting-edge gene editing technologies and a commitment to advancing biological research. Our company has extensive expertise in developing innovative biological products that support and accelerate scientific discoveries, solidifying our reputation as a trusted partner in the field of genetics and metabolic research.

Please note that all services are for research use only. Not intended for any clinical use.

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