Gene: ABCD3
Official Full Name: ATP binding cassette subfamily D member 3provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01046 | ABCD3 Knockout cell line (HeLa) | Human | ABCD3 | 1:3~1:6 | Negative | Online Inquiry |
KO07358 | ABCD3 Knockout cell line (HCT 116) | Human | ABCD3 | 1:2~1:4 | Negative | Online Inquiry |
KO07359 | ABCD3 Knockout cell line (HEK293) | Human | ABCD3 | 1:3~1:6 | Negative | Online Inquiry |
KO07360 | ABCD3 Knockout cell line (A549) | Human | ABCD3 | 1:3~1:4 | Negative | Online Inquiry |
ABCD3 Gene Knockout Cell Lines are specialized cellular models designed to facilitate the study of the ABCD3 gene, which encodes a member of the ATP-binding cassette (ABC) transporters. These cell lines have been meticulously engineered to disrupt the ABCD3 gene, allowing researchers to explore the functional consequences of its absence. By examining the resulting phenotypic changes, researchers can unravel the underlying mechanisms of diseases associated with dysfunctional ABC transporters, such as metabolic disorders and certain neurodegenerative conditions.
The knockout of the ABCD3 gene leads to altered lipid metabolism and impaired transporter function, providing a unique opportunity to investigate cellular pathways involved in peroxisomal biogenesis and fatty acid metabolism. Researchers can utilize these cell lines to assess the impact on cellular homeostasis, drug metabolism, and the potential role of ABCD3 in response to external stimuli. This functional understanding will enhance the development of targeted therapeutics and biomarkers in clinical settings.
What sets our ABCD3 Gene Knockout Cell Lines apart from traditional models is their high fidelity and reproducibility, ensuring that experimental results are robust and reliable. Furthermore, these cell lines are readily adaptable for high-throughput screening, making them invaluable tools for pharmaceutical development and discovery research.
For researchers and clinicians, the ability to dissect the functions of the ABCD3 gene provides significant insights into therapeutic targets and disease mechanisms. Our extensive expertise in gene editing technologies, coupled with a commitment to quality and innovation, positions our company as a leader in providing advanced biological products tailored to meet the demands of cutting-edge research. With ABCD3 Gene Knockout Cell Lines, you can enhance your research outcomes and contribute to groundbreaking advances in medical science.
Please note that all services are for research use only. Not intended for any clinical use.
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