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ABCA5 Knockout Cell Lines

Gene: ABCA5

Official Full Name: ATP binding cassette subfamily A member 5provided by HGNC

Gene Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29284 ABCA5 Knockout cell line (HeLa) Human ABCA5 1:3~1:6 Negative Online Inquiry
KO29285 ABCA5 Knockout cell line (HCT 116) Human ABCA5 1:2~1:4 Negative Online Inquiry
KO29286 ABCA5 Knockout cell line (HEK293) Human ABCA5 1:3~1:6 Negative Online Inquiry
KO29287 ABCA5 Knockout cell line (A549) Human ABCA5 1:3~1:4 Negative Online Inquiry

Background

ABCA5 Gene Knockout Cell Lines are advanced biological research tools designed to facilitate comprehensive studies of the ABCA5 gene's function and its implications in various physiological and pathological processes. These cell lines have been genetically engineered to exhibit a complete knockout of the ABCA5 gene, thereby providing a unique model to investigate the gene's role in lipid metabolism, cell signaling, and disease mechanisms, specifically relating to lipid-related disorders.

The primary function of these knockout cell lines lies in their ability to enable researchers to discern the specific biological pathways that are modulated by the ABCA5 protein. By comparing gene expression profiles, cellular responses, and metabolic activities between wild-type and knockout cells, scientists can elucidate the downstream effects of ABCA5 absence. This systemic approach allows for a deeper understanding of conditions such as atherosclerosis, Alzheimer's disease, and other metabolic syndromes.

In both research and clinical settings, the applications of ABCA5 Gene Knockout Cell Lines are manifold. They serve as valuable platforms for drug discovery, allowing researchers to screen for compounds that can modulate functionally relevant pathways altered by ABCA5 deficiency. Furthermore, they can be employed in preclinical studies to assess therapeutic strategies targeting lipid transport mechanisms.

What sets ABCA5 Gene Knockout Cell Lines apart from other genetic models is their high specificity and robust functionality. Unlike alternative systems that may offer less precision, these cell lines undergo rigorous characterizations to confirm complete gene invalidation, resulting in consistent experimental outcomes. Additionally, their ease of use in standard laboratory protocols makes them accessible to both novice and experienced researchers alike.

Researchers and clinicians will find these knockout cell lines invaluable for advancing their understanding of lipid dynamics and related pathologies. The insights gained from utilizing these models could drive significant breakthroughs in therapeutic targets and strategies.

Our company, a leader in the development of precision gene editing tools, is committed to empowering scientists with innovative solutions that enhance biological research. We provide a diverse portfolio of genetically modified cell lines, ensuring that our customers have access to the highest quality resources for advancing their projects.

Please note that all services are for research use only. Not intended for any clinical use.

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