Gene: ZMIZ1
Official Full Name: zinc finger MIZ-type containing 1provided by HGNC
Gene Summary: This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Mar 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03043 | ZMIZ1 Knockout cell line (HeLa) | Human | ZMIZ1 | 1:3~1:6 | Negative | Online Inquiry |
KO03044 | ZMIZ1 Knockout cell line (HCT 116) | Human | ZMIZ1 | 1:2~1:4 | Negative | Online Inquiry |
KO03045 | ZMIZ1 Knockout cell line (HEK293) | Human | ZMIZ1 | 1:3~1:6 | Negative | Online Inquiry |
KO03046 | ZMIZ1 Knockout cell line (A549) | Human | ZMIZ1 | 1:3~1:4 | Negative | Online Inquiry |
ZMIZ1 Gene Knockout Cell Lines are meticulously engineered human cell lines that have undergone targeted gene knockout to inactivate the ZMIZ1 gene. This gene encodes a protein involved in various pathways, including transcriptional regulation, signaling, and cellular processes related to growth and differentiation. By creating a loss-of-function model for ZMIZ1, researchers can investigate the biological roles it plays in cellular homeostasis, disease mechanisms, and therapeutic responses.
The key function of these knockout cell lines lies in their ability to facilitate the study of ZMIZ1's role in cellular functions. By examining the phenotypic changes and molecular pathways disrupted by the absence of ZMIZ1, scientists can uncover intricate cellular interactions and signaling cascades, particularly in contexts such as cancer biology and immune response regulation. The targeted knockout approach allows for precise manipulation of the gene, resulting in stable and reliable cellular models that can be utilized for functional assays, high-throughput screening, and mechanistic studies.
The scientific importance of ZMIZ1 Gene Knockout Cell Lines extends to their numerous applications in both research and clinical settings. They can be instrumental in elucidating the pathways relevant to disease pathology, drug resistance, and the development of targeted therapies, providing critical insights that can lead to novel therapeutic approaches. Moreover, these knockout models serve as powerful tools for validating therapeutic targets and drug candidates during the preclinical phase of development.
In comparison to traditional knockout techniques, our ZMIZ1 Gene Knockout Cell Lines offer enhanced specificity and reproducibility. By utilizing advanced CRISPR-Cas9 technology, we ensure high efficiency and minimal off-target effects. Other alternatives may not provide the same level of confidence, as they often lack the rigor associated with our proprietary validation processes that confirm successful gene disruption.
This product represents a valuable asset to researchers and clinicians focused on understanding the complexities of cellular mechanisms and disease etiology. By incorporating ZMIZ1 Gene Knockout Cell Lines into their research programs, users gain a critical advantage in exploring gene function and the implications of ZMIZ1 in various physiological and pathological contexts.
Our company specializes in the development of precision-engineered biological tools that empower scientists and clinicians worldwide. With a strong focus on innovation and rigorous quality standards, we are dedicated to advancing research and improving healthcare outcomes through our comprehensive portfolio of biological products.
Please note that all services are for research use only. Not intended for any clinical use.
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