Gene: UBE2K
Official Full Name: ubiquitin conjugating enzyme E2 Kprovided by HGNC
Gene Summary: The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37354 | UBE2K Knockout cell line (HeLa) | Human | UBE2K | 1:3~1:6 | Negative | Online Inquiry |
KO37355 | UBE2K Knockout cell line (HCT 116) | Human | UBE2K | 1:2~1:4 | Negative | Online Inquiry |
KO37356 | UBE2K Knockout cell line (HEK293) | Human | UBE2K | 1:3~1:6 | Negative | Online Inquiry |
KO37357 | UBE2K Knockout cell line (A549) | Human | UBE2K | 1:3~1:4 | Negative | Online Inquiry |
UBE2K Gene Knockout Cell Lines are advanced genetic models designed to facilitate the study of the UBE2K gene's roles in cellular processes such as protein ubiquitination and degradation. These cell lines are engineered using CRISPR/Cas9 technology to achieve precise knockout of the UBE2K gene, enabling researchers to assess the functional consequences of the gene's absence. By creating a controlled environment devoid of UBE2K expression, scientists can delve into its involvement in various biological pathways, thus elucidating its significance in mechanisms like cellular stress response and regulation of signal transduction.
The UBE2K gene is known for its critical involvement in the ubiquitin-proteasome system, where it serves as a ubiquitin-conjugating enzyme. The knockout cell lines allow for direct investigation into how the loss of UBE2K impacts protein homeostasis and the potential accumulation of misfolded or damaged proteins. This has important implications for understanding diseases characterized by dysregulated protein turnover, including neurodegenerative conditions and certain cancers.
In comparison to traditional gene silencing methods, such as siRNA or shRNA, UBE2K Gene Knockout Cell Lines offer permanent and stable loss of gene function, providing researchers with a more robust platform for long-term studies. Additionally, these cell lines are versatile and can be readily integrated into various experimental setups, enhancing their applicability in both basic and translational research.
For researchers and clinicians focused on molecular biology and genetics, the UBE2K Gene Knockout Cell Lines represent an invaluable tool for investigating the intricacies of cellular regulation and disease mechanisms. Their ability to produce consistent and reproducible results makes them essential for advancing scientific knowledge and potential therapeutic strategies.
Our company specializes in providing high-quality biological products, and our expertise in genetic engineering ensures that our UBE2K Gene Knockout Cell Lines meet rigorous scientific standards, inviting confident usage in academic and clinical research settings. From development to application, we are dedicated to supporting discoveries that translate into impactful solutions.
Please note that all services are for research use only. Not intended for any clinical use.
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