Gene: TRIM23
Official Full Name: tripartite motif containing 23provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38962 | TRIM23 Knockout cell line (HeLa) | Human | TRIM23 | 1:3~1:6 | Negative | Online Inquiry |
KO38963 | TRIM23 Knockout cell line (HCT 116) | Human | TRIM23 | 1:2~1:4 | Negative | Online Inquiry |
KO38964 | TRIM23 Knockout cell line (HEK293) | Human | TRIM23 | 1:3~1:6 | Negative | Online Inquiry |
KO38965 | TRIM23 Knockout cell line (A549) | Human | TRIM23 | 1:3~1:4 | Negative | Online Inquiry |
TRIM23 Gene Knockout Cell Lines are genetically engineered cell lines that have undergone precise editing to eliminate the expression of the TRIM23 gene. TRIM23, or Tripartite Motif-Containing Protein 23, is an important member of the TRIM protein family, known for its roles in various cellular processes including immune response, apoptosis, and autophagy. By employing advanced techniques such as CRISPR/Cas9 or homologous recombination, these cell lines provide a valuable tool for researchers aiming to dissect the biological functions of TRIM23 and its involvement in various pathophysiological conditions.
The primary mechanism by which TRIM23 influences cellular functions lies in its ability to modulate key signaling pathways and interact with different cellular proteins, thus impacting processes such as gene regulation and protein degradation. By utilizing TRIM23 gene knockout cell lines, researchers can explore how the absence of this protein affects cellular responses to stress, contributes to disease mechanisms—in particular cancer, autoimmune disorders, and viral infections—and could potentially identify novel therapeutic targets.
In terms of scientific importance, the application of TRIM23 knockout cell lines extends into multiple research domains, including cancer biology, immunology, and virology. Their use can facilitate insights into how loss of TRIM23 alters cellular dynamics, leading to breakthroughs in treatment strategies. Compared to alternative models that may not adequately simulate the specific effects of TRIM23 deletion, these knockout cell lines enable precise investigations, ensuring more reliable and reproducible results.
Researchers and clinicians will find TRIM23 Gene Knockout Cell Lines invaluable for studying complex biological phenomena, generating hypotheses, and validating findings in a controlled environment. This product empowers scientists to push the boundaries of knowledge in gene functionality and disease, ultimately contributing to the advancement of medical science.
With a commitment to quality and innovation, our company specializes in providing cutting-edge biological products that support advanced genomic research. Leveraging our expertise in gene editing technologies, we deliver reliable, scientifically robust tools that enhance experimental rigor and accelerate discovery in health sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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