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TMEM208 Knockout Cell Lines

Gene: TMEM208

Official Full Name: transmembrane protein 208provided by HGNC

Gene Summary: This gene encodes a highly conserved protein which is localized in the endoplasmic reticulum (ER). The protein is linked to autophagy and ER stress. Knockdown of this gene increased autophagy and triggered ER stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06476 TMEM208 Knockout cell line (HeLa) Human TMEM208 1:3~1:6 Negative Online Inquiry
KO06477 TMEM208 Knockout cell line (HCT 116) Human TMEM208 1:2~1:4 Negative Online Inquiry
KO06478 TMEM208 Knockout cell line (HEK293) Human TMEM208 1:3~1:6 Negative Online Inquiry
KO06479 TMEM208 Knockout cell line (A549) Human TMEM208 1:3~1:4 Negative Online Inquiry

Background

TMEM208 Gene Knockout Cell Lines are genetically engineered cell lines designed to facilitate the study of the TMEM208 gene, which encodes a membrane protein implicated in various cellular processes, including cell signaling and metabolism. By systematically knocking out the TMEM208 gene, these cell lines enable researchers to elucidate the functional role of TMEM208 in both normal physiological processes and disease states.

The primary mechanism of action lies in the complete ablation of TMEM208 protein expression, allowing for in-depth investigation of downstream signaling pathways and cellular responses that depend on this protein. This knockout approach is pivotal for understanding the gene's contributions to pathological conditions such as cancer, metabolic disorders, and neurodegenerative diseases. Because TMEM208 is associated with critical cellular functions, the insights gained from these cell lines can potentially lead to the identification of novel therapeutic targets and biomarkers.

Scientifically, the development of TMEM208 Gene Knockout Cell Lines represents a significant advancement in molecular biology, enabling cutting-edge research in gene function and regulation. In clinical settings, these cell lines can facilitate drug screening processes and provide a platform for therapeutic investigations, particularly for conditions linked to the dysfunction of TMEM208.

Compared to traditional models, including wild-type cell lines or animal models, TMEM208 Gene Knockout Cell Lines offer a level of specificity and control that enhances experimental reproducibility and reliability. Researchers benefit from the time-efficient and cost-effective nature of using established cell lines rather than developing their own models from scratch.

Ultimately, the TMEM208 Gene Knockout Cell Lines are invaluable for researchers aiming to unravel the complexities of gene function, aiding in the progress of both basic science and clinical applications. Our company specializes in providing high-quality biological products tailored to advanced research needs, ensuring that scientists have the tools necessary to make groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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