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TLE4 Knockout Cell Lines

Gene: TLE4

Official Full Name: TLE family member 4, transcriptional corepressorprovided by HGNC

Gene Summary: Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within Wnt signaling pathway; cellular response to leukemia inhibitory factor; and negative regulation of DNA-templated transcription. Located in nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11640 TLE4 Knockout cell line (HeLa) Human TLE4 1:3~1:6 Negative Online Inquiry
KO11641 TLE4 Knockout cell line (HEK293) Human TLE4 1:3~1:6 Negative Online Inquiry
KO11642 TLE4 Knockout cell line (A549) Human TLE4 1:3~1:4 Negative Online Inquiry

Background

TLE4 Gene Knockout Cell Lines are genetically modified cell cultures in which the TLE4 gene has been inactivated or “knocked out.” TLE4, or Transducin-Like Enhancer of Split 4, is a member of the groucho/TLE family of transcriptional co-repressors that plays critical roles in regulating gene expression during embryonic development, cell differentiation, and tumorigenesis. The key functionality of these knockout cell lines lies in their ability to elucidate the specific biological pathways and molecular mechanisms that TLE4 mediates, allowing researchers to dissect its role in various physiological and pathological processes.

The TLE4 Gene Knockout Cell Lines serve as a vital tool in both basic research and clinical applications. In research settings, they can be employed to investigate the impact of TLE4 deficiency on cellular functions such as proliferation, apoptosis, and differentiation. This information is crucial for understanding diseases such as cancers, where TLE4 may contribute to tumor progression and resistance to therapy. Clinically, these knockout models can assist in developing targeted therapies or diagnostic tools aimed at modifying TLE4-related pathways.

What sets TLE4 Gene Knockout Cell Lines apart from other genetic tools is their specificity and precision in gene alteration. Unlike traditional methods, which may produce off-target effects or non-specific gene regulation, our knockout cell lines ensure a clear and comprehensive assessment of TLE4's role. This high degree of specificity accelerates research timelines and enhances the reliability of experimental outcomes.

With a robust foundation in genetic modification technologies and extensive expertise in molecular biology, our company is committed to providing superior biological products that meet the evolving needs of researchers and clinicians. TLE4 Gene Knockout Cell Lines not only represent a significant advancement in genetic tools but also embody our dedication to facilitating cutting-edge research and therapeutic development.

Please note that all services are for research use only. Not intended for any clinical use.

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