Gene: TFAP2E
Official Full Name: transcription factor AP-2 epsilonprovided by HGNC
Gene Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and regulation of cell population proliferation. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO13450 | TFAP2E Knockout cell line (HCT 116) | Human | TFAP2E | 1:2~1:4 | Negative | Online Inquiry |
TFAP2E Gene Knockout Cell Lines are genetically modified cells in which the transcription factor AP-2 epsilon (TFAP2E) gene has been disrupted, enabling researchers to study the precise roles and mechanisms of TFAP2E in various biological processes. These cell lines offer an invaluable tool for elucidating the gene’s involvement in critical pathways associated with development, cellular differentiation, and disease states, particularly in cancer and neurodegenerative disorders.
The primary function of TFAP2E is to regulate gene expression through its binding to specific DNA sequences, which can influence cell proliferation and apoptosis. By analyzing these knockout cell lines, researchers can investigate the cascading effects of TFAP2E loss on cellular behavior and signaling pathways. The use of these models helps to reveal both the physiological roles of this transcription factor and its potential implications as a therapeutic target.
In terms of scientific importance, the availability of TFAP2E Gene Knockout Cell Lines is crucial for advancing our understanding of transcriptional regulation and its impact on human health. In clinical research, these models can facilitate drug discovery efforts aimed at diseases where TFAP2E plays a significant role, providing a platform for testing new therapeutic compounds.
Compared to traditional methods such as siRNA knockdown or overexpression systems, TFAP2E Gene Knockout Cell Lines offer a more stable and permanent solution to investigate gene function, avoiding transient effects or off-target effects typically associated with other techniques. This allows for more consistent, reproducible results over prolonged periods, which is critical for comprehensive studies.
For researchers and clinicians alike, leveraging these knockout cell lines can accelerate discovery and innovation in genomics and therapeutic development. Our expertise in generating high-quality recombinant biological products and a commitment to supporting cutting-edge research uniquely positions us to contribute to advancements in gene editing technologies. Trust in our TFAP2E Gene Knockout Cell Lines to provide robust insights that further your scientific endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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