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TCN1 Knockout Cell Lines

Gene: TCN1

Official Full Name: transcobalamin 1provided by HGNC

Gene Summary: This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This protein is a major constituent of secondary granules in neutrophils and facilitates the transport of cobalamin into cells. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20676 TCN1 Knockout cell line (HCT 116) Human TCN1 1:2~1:4 Negative Online Inquiry

Background

TCN1 Gene Knockout Cell Lines are highly specialized cellular models engineered to disrupt the expression of the TCN1 gene, which encodes for the transcobalamin I protein involved in Vitamin B12 transport and metabolism. Utilizing CRISPR-Cas9 technology, these knockout cell lines are designed to serve as critical tools in the study of Vitamin B12 deficiency and its implications in various biological processes and diseases.

The primary function of TCN1 Gene Knockout Cell Lines lies in their ability to facilitate research into the cellular and molecular ramifications of impaired cobalamin transport. Researchers can examine changes in metabolic pathways, gene expression patterns, and cellular responses to Vitamin B12 availability. This model helps elucidate the role of TCN1 in intracellular transport mechanisms and its influence on physiological states, potentially leading to breakthroughs in understanding related disorders.

Scientifically, these cell lines are invaluable in both research and clinical settings, providing a means to investigate the pathophysiology of disorders linked to Vitamin B12 dysregulation, such as megaloblastic anemia and neurological conditions. With applications extending to drug discovery and therapeutic interventions, TCN1 knockout cell lines enable a deeper investigation that can inform clinical practices and improve patient outcomes.

What sets TCN1 Gene Knockout Cell Lines apart from alternatives is their precise genetic modification, allowing for reproducibility and reliability in experimental design. Unlike traditional cell lines, these knockout models provide a more accurate representation of the physiological perturbations resulting from gene loss, thus enhancing the validity of experimental findings.

For researchers and clinicians seeking to explore the complexities of Vitamin B12 metabolism and its systemic effects, TCN1 Gene Knockout Cell Lines offer a significant advantage as a customizable, precise, and impactful research tool. As an innovative company deeply committed to advancing cellular biology, we provide high-quality, validated models that empower the scientific community to make meaningful discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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