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RMI2 Knockout Cell Lines

Gene: RMI2

Official Full Name: RecQ mediated genome instability 2provided by HGNC

Gene Summary: RMI2 is a component of the BLM (RECQL3; MIM 604610) complex, which plays a role in homologous recombination-dependent DNA repair and is essential for genome stability (Xu et al., 2008 [PubMed 18923082]).[supplied by OMIM, Nov 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03662 RMI2 Knockout cell line (HeLa) Human RMI2 1:3~1:6 Negative Online Inquiry
KO03663 RMI2 Knockout cell line (HCT 116) Human RMI2 1:2~1:4 Negative Online Inquiry
KO03664 RMI2 Knockout cell line (HEK293) Human RMI2 1:3~1:6 Negative Online Inquiry
KO03665 RMI2 Knockout cell line (A549) Human RMI2 1:3~1:4 Negative Online Inquiry

Background

RMI2 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to study the functional role of the RMI2 gene, known for its involvement in DNA replication and repair processes. These knockout models facilitate an in-depth analysis of the RMI2 gene's contributions to cellular functions by enabling researchers to observe the effects of its absence on various biological pathways.

The key function of RMI2 is associated with its role as a component of the resolvase complex, which is critical for resolving Holliday junctions during DNA replication. By utilizing CRISPR-Cas9 technology, our RMI2 Gene Knockout Cell Lines exhibit targeted deletions of RMI2, allowing scientists to investigate subsequent phenotypic changes, such as replication stress, genome stability, and cellular response to DNA damage. This mechanism provides unparalleled insights into how RMI2 influences cellular behavior and how its dysregulation may lead to oncogenesis.

The scientific importance of RMI2 Gene Knockout Cell Lines extends into diverse research areas including cancer biology, drug development, and gene therapy. Researchers employ these models to elucidate the molecular basis of genomic instability commonly observed in tumors, ultimately enhancing understanding of cancer pathogenesis and potential therapeutic targets.

Unlike traditional knockout methods, our RMI2 cell lines offer precise gene editing capabilities, replicating physiological conditions with minimal off-target effects. This ensures high reproducibility and reliability in results, providing a significant advantage over alternative models that do not replicate the native cellular environment as accurately.

For researchers and clinicians, the RMI2 Gene Knockout Cell Lines represent a critical tool in advancing the frontiers of genetic research and therapeutic strategies. By facilitating rigorous studies of DNA repair mechanisms, these cell lines can significantly contribute to innovative approaches in treating genetic disorders and cancer.

Our company specializes in cutting-edge genetic engineering technologies and is committed to empowering researchers with high-quality biological products that fuel scientific discovery and innovation. With our expertise, we aim to establish a strong partnership with the research community for efficient and meaningful advancements in understanding gene function.

Please note that all services are for research use only. Not intended for any clinical use.

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