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RIF1 Knockout Cell Lines

Gene: RIF1

Official Full Name: replication timing regulatory factor 1provided by HGNC

Gene Summary: This gene encodes a protein that shares homology with the yeast teleomere binding protein, Rap1 interacting factor 1. This protein localizes to aberrant telomeres may be involved in DNA repair. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO14536 RIF1 Knockout cell line (HeLa) Human RIF1 1:3~1:6 Negative Online Inquiry
KO14537 RIF1 Knockout cell line (HCT 116) Human RIF1 1:2~1:4 Negative Online Inquiry
KO14538 RIF1 Knockout cell line (HEK293) Human RIF1 1:3~1:6 Negative Online Inquiry
KO14539 RIF1 Knockout cell line (A549) Human RIF1 1:3~1:4 Negative Online Inquiry

Background

RIF1 Gene Knockout Cell Lines are genetically engineered derivatives of specific cell lines in which the RIF1 gene has been inactivated, allowing for the investigation of its biological roles and implications in various cellular processes. The RIF1 gene encodes a protein that is crucial for maintaining genome stability, regulating DNA repair mechanisms, and modulating the cellular response to DNA damage. By creating knockout models, researchers can elucidate the pathways mediated by RIF1 and assess its contributions to cellular stress responses, replication timing, and chromatin organization.

Functionally, RIF1 knockout cell lines exhibit altered DNA damage repair kinetics, making them valuable tools for studying the molecular underpinnings of genomic stability and tumorigenesis. These models enable scientists to dissect the functional interplay between RIF1 and other cellular components involved in DNA repair, thereby providing insights into cancer biology and therapeutic resistance. The gene knockout approach is particularly significant in translational research as it can lead to potential targets for novel therapies for conditions linked to DNA repair deficiencies, including various cancers.

What sets RIF1 Gene Knockout Cell Lines apart from other genetic models is their specificity; these cell lines reflect physiologically relevant conditions that provide a more accurate representation of human cellular responses compared to other plasmid-based systems. Additionally, researchers benefit from the ease of reproducibility and consistency in experiments, enhancing the credibility of their findings.

The value of RIF1 Gene Knockout Cell Lines lies in their ability to facilitate groundbreaking discoveries in cellular biology and genetics, empowering researchers and clinicians to explore the complexities of DNA repair in health and disease. By choosing this product, users gain access to cutting-edge tools that can significantly advance their research outcomes.

Established as a leader in the development of high-quality biological products, our company ensures that every RIF1 Gene Knockout Cell Line is meticulously characterized and validated, positioning us as a trusted partner in scientific advancement.

Please note that all services are for research use only. Not intended for any clinical use.

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