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RAB11B Knockout Cell Lines

Gene: RAB11B

Official Full Name: RAB11B, member RAS oncogene familyprovided by HGNC

Gene Summary: The Ras superfamily of small GTP-binding proteins, which includes the Ras (see MIM 190020), Ral (see MIM 179550), Rho (see MIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508) families, is involved in controlling a diverse set of essential cellular functions. The Rab family, including RAB11B, appears to play a critical role in regulating exocytotic and endocytotic pathways (summary by Zhu et al., 1994 [PubMed 7811277]).[supplied by OMIM, Nov 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07405 RAB11B Knockout cell line (HeLa) Human RAB11B 1:3~1:6 Negative Online Inquiry
KO07406 RAB11B Knockout cell line (HCT 116) Human RAB11B 1:2~1:4 Negative Online Inquiry
KO07407 RAB11B Knockout cell line (HEK293) Human RAB11B 1:3~1:6 Negative Online Inquiry
KO07408 RAB11B Knockout cell line (A549) Human RAB11B 1:3~1:4 Negative Online Inquiry

Background

RAB11B Gene Knockout Cell Lines are genetically engineered cellular models designed specifically for studying the functional role of the RAB11B gene, which is crucial for intracellular trafficking and endosomal recycling processes. By utilizing advanced CRISPR/Cas9 technology, these knockout cell lines demonstrate a complete depletion of RAB11B expression, allowing researchers to investigate the gene’s contribution to various cellular functions and its implications in diseases such as cancer and neurodegeneration.

The RAB11B protein is a member of the RAB family of GTPases, specifically involved in regulating endosomal transport and recycling of cellular membranes and proteins. The knockout of RAB11B in these cell lines disrupts normal vesicular trafficking, providing a model to study alterations in intracellular pathways. Researchers can observe changes in cellular processes, such as signaling pathways, membrane turnover, and protein localization, facilitating deeper insights into the molecular mechanisms underlying various pathologies.

These cell lines hold significant scientific importance as they enable the investigation of RAB11B's role across multiple research domains, from fundamental molecular biology to translational studies in cancer therapy and neurobiology. Furthermore, the specific knockout of RAB11B offers a clear advantage over traditional cell lines, which may still express low levels of the target gene, thereby impacting experimental outcomes and interpretations.

What sets RAB11B Gene Knockout Cell Lines apart is their high specificity and reproducibility, enabling researchers to obtain consistent results across multiple experiments. This specificity allows for a more refined dissection of the biological processes involving RAB11B, establishing a robust foundation for subsequent studies and potential therapeutic applications.

For researchers and clinicians seeking to deepen their understanding of intracellular processes or explore new therapeutic avenues, RAB11B Gene Knockout Cell Lines represent a valuable asset. With cutting-edge technology and a commitment to high quality, our company stands as a trusted provider of innovative biological products, facilitating advancements in research and clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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