Gene: PIGG
Official Full Name: phosphatidylinositol glycan anchor biosynthesis class G (EMM blood group)provided by HGNC
Gene Summary: This gene encodes an enzyme involved in glycosylphosphatidylinositol-anchor biosynthesis. The encoded protein, which is localized to the endoplasmic reticulum, is involved in transferring ethanoloamine phosphate to mannose 2 of glycosylphosphatidylinositol species H7 to form species H8. Allelic variants of this gene have been associated with intellectual disability, hypotonia, and early-onset seizures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15139 | PIGG Knockout cell line (HeLa) | Human | PIGG | 1:3~1:6 | Negative | Online Inquiry |
KO15140 | PIGG Knockout cell line (HCT 116) | Human | PIGG | 1:2~1:4 | Negative | Online Inquiry |
KO15141 | PIGG Knockout cell line (HEK293) | Human | PIGG | 1:3~1:6 | Negative | Online Inquiry |
KO15142 | PIGG Knockout cell line (A549) | Human | PIGG | 1:3~1:4 | Negative | Online Inquiry |
PIGG Gene Knockout Cell Lines are specifically engineered cellular models that facilitate the study of the PIGG gene, which plays a crucial role in glycosylation processes essential for cellular function. These cell lines feature a targeted deletion of the PIGG gene, thereby allowing researchers to investigate the biological implications and pathways influenced by the absence of PIGG. The mechanisms through which these knockout cell lines operate involve the modulation of glycan structures on the cell surface and the associated downstream effects on cellular communication, adhesion, and differentiation.
The scientific significance of PIGG Gene Knockout Cell Lines is underscored by their application in both fundamental research and clinical investigations. They serve as powerful tools for unraveling the complexities of glycosylation-related diseases, such as congenital disorders of glycosylation (CDG), and can help in screening potential therapeutic strategies or drug candidates that target the underlying mechanisms of these conditions. By providing a reliable in vitro model, these cell lines enable extensive studies that can lead to advancements in personalized medicine.
One of the distinctive advantages of the PIGG Gene Knockout Cell Lines is their high fidelity in reflecting native cellular behaviors compared to other knockout models. Additionally, their ability to maintain genomic stability and offer consistent experimental results sets them apart from alternatives. Researchers and clinicians benefit from the robust performance of these cell lines, leading to significant time and cost savings in experimental design and execution.
In an era where understanding genetic functions is paramount, the value of PIGG Gene Knockout Cell Lines cannot be overstated. They offer an unparalleled opportunity for the advancement of glycosylation research, paving the way for potential breakthroughs in diagnostics and therapeutics. Our company prides itself on delivering high-quality, validated biological products with a commitment to excellence in research support, ensuring that our clients have access to the very best tools to achieve their scientific goals.
Please note that all services are for research use only. Not intended for any clinical use.
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