Gene: PDZD8
Official Full Name: PDZ domain containing 8provided by HGNC
Gene Summary: Predicted to enable lipid binding activity and metal ion binding activity. Involved in several processes, including mitochondrial calcium ion homeostasis; mitochondrion-endoplasmic reticulum membrane tethering; and regulation of cell morphogenesis. Located in endoplasmic reticulum membrane and mitochondria-associated endoplasmic reticulum membrane contact site. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO30382 | PDZD8 Knockout cell line (HeLa) | Human | PDZD8 | 1:3~1:6 | Negative | Online Inquiry |
KO30383 | PDZD8 Knockout cell line (HCT 116) | Human | PDZD8 | 1:2~1:4 | Negative | Online Inquiry |
KO30384 | PDZD8 Knockout cell line (HEK293) | Human | PDZD8 | 1:3~1:6 | Negative | Online Inquiry |
KO30385 | PDZD8 Knockout cell line (A549) | Human | PDZD8 | 1:3~1:4 | Negative | Online Inquiry |
PDZD8 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to eliminate the expression of the PDZD8 gene, an important player in cellular processes such as endosomal trafficking and cellular signaling. By successfully knocking out the PDZD8 gene, these cell lines serve as powerful tools for researchers to investigate the biological implications of PDZD8 loss-of-function in various cellular contexts.
The manipulation of the PDZD8 gene leads to alterations in membrane dynamics and intracellular signaling pathways, which can further elucidate its role in cellular homeostasis, disease pathology, and therapeutic responsiveness. The knockout mechanism utilizes advanced CRISPR/Cas9 technology, ensuring precise edits to the genome, thereby increasing reliability and reproducibility in experimental designs. The ability to create and study PDZD8-deficient cellular models enables scientists to examine the gene’s contribution to conditions like neurodegenerative diseases and cancer, where abnormal cellular signaling plays a critical role.
Moreover, PDZD8 Gene Knockout Cell Lines offer significant advantages over traditional experimental models. The targeted gene disruption allows for a comprehensive understanding of gene function in a controlled environment, offering greater specificity than pharmacological inhibitors or RNA interference methods. These cell lines can also be employed in high-throughput screening applications to identify compounds that modulate relevant pathways, making them invaluable to both basic research and drug development.
For researchers and clinicians aiming to deepen their understanding of gene function and its implications in health and disease, PDZD8 Gene Knockout Cell Lines present a unique opportunity. They facilitate critical discoveries that could pave the way for novel therapeutic approaches. Our company is committed to providing high-quality, expertly validated biological products. With our extensive experience in genetic engineering and cellular biology, we ensure that our offerings meet the highest standards of scientific integrity, contributing to advancements across a range of research disciplines.
Please note that all services are for research use only. Not intended for any clinical use.
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