Gene: OAZ3
Official Full Name: ornithine decarboxylase antizyme 3provided by HGNC
Gene Summary: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake; however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. Alternatively spliced transcript variants encoding different isoforms, including one resulting from the use of non-AUG (CUG) translation initiation codon, have been found for this gene. [provided by RefSeq, Dec 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO22282 | OAZ3 Knockout cell line (HeLa) | Human | OAZ3 | 1:3~1:6 | Negative | Online Inquiry |
KO22283 | OAZ3 Knockout cell line (HCT 116) | Human | OAZ3 | 1:2~1:4 | Negative | Online Inquiry |
KO22284 | OAZ3 Knockout cell line (HEK293) | Human | OAZ3 | 1:3~1:6 | Negative | Online Inquiry |
KO22285 | OAZ3 Knockout cell line (A549) | Human | OAZ3 | 1:3~1:4 | Negative | Online Inquiry |
OAZ3 Gene Knockout Cell Lines are specifically engineered cellular models created to facilitate the comprehensive study of the OAZ3 gene and its regulatory functions in various biological processes. These cell lines have been meticulously developed using CRISPR/Cas9 technology to induce site-specific mutations in the OAZ3 gene, leading to a complete loss of its expression. As a result, researchers can investigate the downstream effects of OAZ3 absence, particularly its role in polyamine metabolism and cellular differentiation.
The primary function of the OAZ3 Gene Knockout Cell Lines lies in their ability to serve as a powerful tool for dissecting the molecular pathways influenced by the OAZ3 gene. By observing changes in cell proliferation, apoptosis, and metabolic activity, researchers can gain critical insights into how OAZ3 contributes to cellular homeostasis. The absence of this gene provides a unique model for studying its involvement in conditions such as cancer, where dysregulation of polyamine metabolism is often implicated.
In scientific research and clinical settings, these knockout cell lines play an essential role in drug discovery, biomarker identification, and therapeutic development. With the burgeoning interest in gene therapy and personalized medicine, OAZ3 Gene Knockout Cell Lines represent a valuable asset for target validation, aiding the development of innovative treatment strategies.
What sets these cell lines apart from alternatives is their high specificity and reliability, enabling reproducible results across experiments. Moreover, their customizable nature allows researchers to adapt the models for various applications, ensuring flexibility in experimental design.
For researchers and clinicians striving to unlock the complexities of genetic regulation and its associated pathologies, OAZ3 Gene Knockout Cell Lines offer an invaluable avenue to explore fundamental biological questions. Additionally, our company, with its extensive expertise in genetic engineering and cell line development, delivers these models with the highest quality assurance, ensuring that researchers can depend on our products to yield meaningful insights in their scientific endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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