Gene: MAPK1
Official Full Name: mitogen-activated protein kinase 1provided by HGNC
Gene Summary: This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11530 | MAPK1 Knockout cell line (HeLa) | Human | MAPK1 | 1:3~1:6 | Negative | Online Inquiry |
KO11531 | MAPK1 Knockout cell line (HCT 116) | Human | MAPK1 | 1:2~1:4 | Negative | Online Inquiry |
KO11532 | MAPK1 Knockout cell line (HEK293) | Human | MAPK1 | 1:3~1:6 | Negative | Online Inquiry |
KO11533 | MAPK1 Knockout cell line (A549) | Human | MAPK1 | 1:3~1:4 | Negative | Online Inquiry |
MAPK1 Gene Knockout Cell Lines are genetically modified cell lines in which the MAPK1 (Mitogen-Activated Protein Kinase 1) gene has been entirely disrupted or "knocked out." This gene is crucial for various cellular processes, including growth, differentiation, and response to stress signals. By developing these knockout cell lines, researchers can study the implications of MAPK1 loss on cell behavior, signaling pathways, and associated physiological functions.
The primary function of MAPK1 gene knockout cell lines is to provide a powerful tool for elucidating the role of MAPK1 in oncogenesis, cell proliferation, and apoptosis. The mechanisms of action include the disruption of MAPK signaling cascades, leading to altered cellular responses to growth factors and stress. This model enables scientists to observe the comprehensive effects of knocking out MAPK1, including changes in gene expression profiles, cell cycle dynamics, and metabolic shifts.
In research and clinical settings, these cell lines hold significant scientific importance, particularly in cancer research, drug discovery, and developmental biology. Investigating the functional consequences of MAPK1 knockout can provide insights into targeted therapies for cancers where MAPK signaling is dysregulated. Furthermore, this product accelerates the discovery of therapeutic options by allowing for the quick analysis of novel pharmacological agents and their impact on MAPK1-related pathways.
The advantages of MAPK1 Gene Knockout Cell Lines over traditional methods include the precision in gene editing achieved through CRISPR-Cas9 techniques and the reproducibility of experiments. Unlike alternative models, these knockout cell lines provide a homogenous population of cells with a consistent genetic background, ensuring that the results are reliable and not confounded by genetic variability.
For researchers and clinicians, investing in MAPK1 Gene Knockout Cell Lines represents an invaluable opportunity to advance their studies on cancer biology and therapeutic interventions. The ability to manipulate key genetic pathways efficiently and effectively directly translates into enhanced research productivity and innovation in treatment strategies.
Our company specializes in high-quality biological products and genetic models, leveraging advanced gene editing technologies to provide researchers with tools that push the boundaries of current scientific understanding. By using our MAPK1 Gene Knockout Cell Lines, you can ensure robust and impactful research outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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