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LRP3 Knockout Cell Lines

Gene: LRP3

Official Full Name: LDL receptor related protein 3provided by HGNC

Gene Summary: Involved in negative regulation of fat cell differentiation; positive regulation of osteoblast differentiation; and regulation of gene expression. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06006 LRP3 Knockout cell line (HeLa) Human LRP3 1:3~1:6 Negative Online Inquiry
KO06007 LRP3 Knockout cell line (HCT 116) Human LRP3 1:2~1:4 Negative Online Inquiry
KO06008 LRP3 Knockout cell line (HEK293) Human LRP3 1:3~1:6 Negative Online Inquiry
KO06009 LRP3 Knockout cell line (A549) Human LRP3 1:3~1:4 Negative Online Inquiry

Background

LRP3 Gene Knockout Cell Lines are innovative biological tools engineered to facilitate the specific ablation of the LRP3 gene, essential in studying its role in various physiological and pathological processes. These cell lines are created through cutting-edge CRISPR-Cas9 technology, ensuring precise excision of the gene, which allows researchers to investigate the functional consequences of LRP3 deletion without interference from native alleles.

The key function of LRP3 knockout cell lines lies in their ability to provide a controlled environment for examining the cellular and molecular mechanisms influenced by LRP3. By utilizing these knockout models, researchers can dissect the pathways associated with protein interactions, signaling cascades, and the overall impact on cellular homeostasis. This functionality is critical in the fields of genetic research, drug discovery, and disease modeling, particularly for conditions where LRP3 may play a pivotal role, such as obesity, metabolic disorders, and various cancers.

The scientific importance of LRP3 knockout cell lines cannot be overstated, as they provide invaluable insights into gene function and regulation. In clinical research settings, these models offer a platform for testing the efficacy of therapeutic agents aimed at modulating LRP3 pathways, thereby contributing to the development of targeted treatments. Additionally, these cell lines facilitate high-throughput screening applications, enabling researchers to explore pharmacological interventions with greater efficiency.

Compared to traditional methods of gene knockout, such as homologous recombination, CRISPR-Cas9-derived LRP3 knockout cell lines present several advantages, including reduced time frame for gene editing, higher efficiency, and the ability to generate multiple knockouts in a single cell line or across different cellular contexts. This allows for greater flexibility and specificity in experimental design.

The value of LRP3 Gene Knockout Cell Lines is further underscored by their contributions to advancing our understanding of complex biological systems and the emergence of innovative pathways in therapeutic development. Researchers and clinicians seeking to explore the consequences of LRP3 depletion will find these tools indispensable in their work.

As an industry leader with a strong commitment to advancing molecular biology tools, our company specializes in providing high-quality, rigorously validated cell lines and genetic products, ensuring that researchers have access to the best resources for their scientific endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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