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LILRA3 Knockout Cell Lines

Gene: LILRA3

Official Full Name: leukocyte immunoglobulin like receptor A3provided by HGNC

Gene Summary: This gene encodes a member of a family of immunoreceptors that are expressed predominantly in monocytes and B cells, and at lower levels in dendritic cells and natural killer cells. The encoded protein lacks the transmembrane region found in other members of this family. It acts as a soluble receptor for class I major histocompatibility complex (MHC) antigens. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and is polymorphic in human populations, with many individuals containing a deletion of this genomic region. [provided by RefSeq, Mar 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31299 LILRA3 Knockout cell line (HeLa) Human LILRA3 1:3~1:6 Negative Online Inquiry
KO31300 LILRA3 Knockout cell line (HCT 116) Human LILRA3 1:2~1:4 Negative Online Inquiry
KO31301 LILRA3 Knockout cell line (HEK293) Human LILRA3 1:3~1:6 Negative Online Inquiry
KO31302 LILRA3 Knockout cell line (A549) Human LILRA3 1:3~1:4 Negative Online Inquiry

Background

LILRA3 Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to study the role of the LILRA3 gene, a member of the leukocyte immunoglobulin-like receptor (LIR) family implicated in modulating immune responses. These knockout cell lines have been meticulously created using CRISPR/Cas9 technology, ensuring a complete disruption of the LILRA3 gene, thereby providing researchers with a powerful tool to dissect the genetic and functional attributes associated with this receptor's activity.

Key functions of LILRA3 include its involvement in immune cell signaling and modulation of inflammatory responses, which are pivotal in understanding various pathological conditions, such as autoimmune diseases and cancer. By utilizing these knockout cell lines, researchers can explore the mechanisms by which LILRA3 mediates interactions between immune cells and their microenvironment, facilitating the identification of potential therapeutic targets.

The scientific importance of LILRA3 Gene Knockout Cell Lines cannot be overstated, as they serve crucial roles in enhancing the understanding of immune regulation in both research and clinical settings. Their application extends to drug discovery, where evaluating the cellular responses in the absence of LILRA3 can unveil novel pathways and therapeutic strategies aimed at modulating immune function.

One of the distinct advantages of our LILRA3 Gene Knockout Cell Lines lies in their high specificity and reliability compared to traditional models, such as wild-type cells or those with non-targeted mutations. Moreover, these knockout lines allow for reproducible studies without the confounding effects of unintended genetic variations, yielding more accurate and interpretable data.

For researchers, clinicians, and biotechnology firms, the value of LILRA3 Gene Knockout Cell Lines is immense; they provide an unparalleled opportunity to study immune mechanisms in a controlled environment, paving the way for breakthroughs in immunology and therapeutic interventions. Our company, rooted in extensive expertise in genetic engineering and cellular biology, ensures that these cell lines are produced under rigorous quality standards, fostering innovation and supporting research endeavors in the biological sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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