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IRF5 Knockout Cell Lines

Gene: IRF5

Official Full Name: interferon regulatory factor 5provided by HGNC

Gene Summary: This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01867 IRF5 Knockout cell line (HCT 116) Human IRF5 1:2~1:4 Negative Online Inquiry
KO01868 IRF5 Knockout cell line (HEK293) Human IRF5 1:3~1:6 Negative Online Inquiry
KO01869 IRF5 Knockout cell line (A549) Human IRF5 1:3~1:4 Negative Online Inquiry

Background

IRF5 Gene Knockout Cell Lines are genetically engineered cell lines designed to lack the Interferon Regulatory Factor 5 (IRF5) gene, which plays a critical role in immune response regulation, particularly in the context of inflammation and autoimmunity. By creating these knockout models, researchers can investigate the role of IRF5 in various biological processes, including cytokine production, T-cell activation, and innate immune responses.

The mechanisms underlying the utility of these cell lines involve the disruption of IRF5-dependent signaling pathways, thus allowing for the examination of the downstream effects on gene expression and cellular behavior. Such models are crucial for elucidating the pathophysiology of diseases linked to dysregulated immune responses, including systemic lupus erythematosus and rheumatoid arthritis.

The scientific importance of IRF5 Gene Knockout Cell Lines is evident in their widespread applications in both basic research and clinical investigations. They serve as powerful tools for identifying therapeutic targets and testing potential drugs aimed at modulating immune function. Furthermore, these cell lines enable researchers to explore new dimensions of immunotherapy, making them invaluable for drug development and discovery.

What sets our IRF5 Gene Knockout Cell Lines apart from traditional models is their precision and reliability in mimicking the loss of IRF5 function. Unlike transient knockdown approaches, these stable lineages offer reproducibility and consistency across experiments. This unique feature is crucial for long-term studies and robust data generation.

For researchers and clinicians focused on understanding autoimmune conditions or developing novel treatments, these cell lines represent a transformative resource that empowers scientific inquiry and innovation. Our company specializes in delivering high-quality biological products designed to advance research and therapeutic outcomes, and our expertise ensures that you receive scientifically validated models tailored to your specific needs.

Please note that all services are for research use only. Not intended for any clinical use.

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