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GALNT5 Knockout Cell Lines

Gene: GALNT5

Official Full Name: polypeptide N-acetylgalactosaminyltransferase 5provided by HGNC

Gene Summary: The protein encoded by this gene is a membrane-bound polypeptide N-acetylgalactosaminyltransferase that is found in the Golgi. The encoded protein catalyzes the first step in the mucin-type O-glycosylation of Golgi proteins, transfering an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. [provided by RefSeq, Aug 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31039 GALNT5 Knockout cell line (HCT 116) Human GALNT5 1:2~1:4 Negative Online Inquiry
KO31040 GALNT5 Knockout cell line (A549) Human GALNT5 1:3~1:4 Negative Online Inquiry

Background

GALNT5 Gene Knockout Cell Lines are specialized cellular models in which the GALNT5 gene has been systematically disrupted, allowing for the functional analysis of this gene and its associated biological pathways. GALNT5 encodes an enzyme involved in the O-glycosylation of proteins, playing a crucial role in glycan synthesis that affects various cellular processes, including cell signaling, adhesion, and immune responses. By utilizing these knockout cell lines, researchers can investigate the physiological implications of GALNT5 deficiency and its contribution to pathological conditions, such as cancer progression and developmental disorders.

The key functions of GALNT5 are elucidated through the physiological effects observed in knockout models, where the absence of this gene can lead to altered protein glycosylation patterns. This potential shifts cellular interactions and signaling pathways, providing insights into essential biological mechanisms. Such models enable researchers to dissect the role of GALNT5 in cellular architecture, mobility, and metabolic regulation, presenting invaluable data for advancing therapeutic strategies.

The scientific importance of GALNT5 Gene Knockout Cell Lines extends to both fundamental research and clinical applications. In biomedical research, they serve as critical tools for understanding the molecular basis of glycosylation-related diseases and identifying novel drug targets. Clinically, these models may aid in predicting responses to glycan-targeted therapies and facilitate the development of more effective treatment modalities for patients with glycosylation defects.

What sets GALNT5 Gene Knockout Cell Lines apart from alternatives is their precision and reliability in gene editing, supported by advanced CRISPR/Cas9 technology and rigorous validation processes. Additionally, these models come with comprehensive technical support and detailed user guides, ensuring that researchers can maximize their utility without extensive preparatory work.

For investigators and clinicians seeking to deepen their understanding of glycosylation and its implications in health and disease, GALNT5 Gene Knockout Cell Lines offer superior value. These products are designed to streamline research efforts, accelerate discoveries, and contribute to the development of innovative therapeutics.

Our company has extensive experience and expertise in creating cutting-edge biological products tailored for research and clinical needs, ensuring that our offerings are not only state-of-the-art but also relevant and applicable to the ever-evolving field of molecular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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