Gene: FAM53B
Official Full Name: family with sequence similarity 53 member Bprovided by HGNC
Gene Summary: Involved in positive regulation of canonical Wnt signaling pathway. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32931 | FAM53B Knockout cell line (HeLa) | Human | FAM53B | 1:3~1:6 | Negative | Online Inquiry |
KO32932 | FAM53B Knockout cell line (HCT 116) | Human | FAM53B | 1:2~1:4 | Negative | Online Inquiry |
KO32933 | FAM53B Knockout cell line (HEK293) | Human | FAM53B | 1:3~1:6 | Negative | Online Inquiry |
KO32934 | FAM53B Knockout cell line (A549) | Human | FAM53B | 1:3~1:4 | Negative | Online Inquiry |
FAM53B Gene Knockout Cell Lines are a specialized set of genetically modified cell lines in which the FAM53B gene has been functionally disrupted. The FAM53B gene encodes a protein implicated in various cellular processes, including cell proliferation and differentiation. By creating knockout versions of this gene, researchers can investigate its specific role in cellular functions, disease mechanisms, and potential therapeutic targets.
The key function of FAM53B Gene Knockout Cell Lines lies in their ability to elucidate the consequences of FAM53B gene loss. This is achieved through the use of CRISPR-Cas9 technology, which allows for precise edits in the genomic DNA, resulting in a loss-of-function effect that enables detailed studies of downstream signaling pathways and gene interactions. By comparing the knockout cells with their wild-type counterparts, researchers can discern critical biological roles played by the FAM53B protein, thus highlighting its potential contributions to pathological conditions, such as cancer and metabolic disorders.
The scientific importance of these cell lines is paramount, as they serve as invaluable tools in both basic and applied research settings. They provide insights into gene function, facilitate the exploration of gene therapy approaches, and can be instrumental in drug discovery efforts targeted at diseases associated with FAM53B dysregulation. Their application in various cellular models contributes to a deeper understanding of gene-environment interactions, which is essential for the development of personalized medicine.
What sets FAM53B Gene Knockout Cell Lines apart from alternative models is their high specificity and reliability, as well as the robustness of the CRISPR-Cas9 editing technique. In contrast to conventional knockdown strategies that may only partially inhibit gene expression, these knockout lines offer a complete loss of function, thereby providing more definitive insights into gene activity.
For researchers and clinicians looking to investigate the molecular basis of diseases, the value of FAM53B Gene Knockout Cell Lines is evident. They not only enhance the understanding of gene roles in pathophysiology but also pave the way for developing targeted therapies that could improve patient outcomes.
With extensive expertise in developing cutting-edge biological products and a commitment to advancing research capabilities, our company ensures high-quality FAM53B Gene Knockout Cell Lines tailored to the needs of the scientific community. We are dedicated to supporting your research with innovative solutions that drive discovery and enhance therapeutic strategies.
Please note that all services are for research use only. Not intended for any clinical use.
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