Gene: COX8A
Official Full Name: cytochrome c oxidase subunit 8Aprovided by HGNC
Gene Summary: The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38460 | COX8A Knockout cell line (HeLa) | Human | COX8A | 1:3~1:6 | Negative | Online Inquiry |
KO38461 | COX8A Knockout cell line (HCT 116) | Human | COX8A | 1:2~1:4 | Negative | Online Inquiry |
KO38462 | COX8A Knockout cell line (HEK293) | Human | COX8A | 1:3~1:6 | Negative | Online Inquiry |
KO38463 | COX8A Knockout cell line (A549) | Human | COX8A | 1:3~1:4 | Negative | Online Inquiry |
COX8A Gene Knockout Cell Lines represent a pivotal advancement in cellular biology, specifically designed for the study of mitochondrial function and energy metabolism. These cell lines have been engineered to stably silence the COX8A gene, which encodes a critical subunit of cytochrome c oxidase, a key enzyme in the mitochondrial respiratory chain. By disrupting this gene, researchers gain invaluable insights into the role of mitochondrial dysfunction in various physiological and pathological conditions.
The primary mechanism underlying the utility of COX8A Gene Knockout Cell Lines lies in their ability to mimic disease states that feature impaired cellular respiration. As a result, these cell lines serve as an indispensable tool for studying the implications of mitochondrial dysfunction in a range of conditions, including neurodegenerative disorders, metabolic syndromes, and cancer. They enable researchers to investigate the downstream effects of COX8A loss on cellular energy production, oxidative stress responses, and metabolic adaptations.
From a scientific perspective, the applications of COX8A Gene Knockout Cell Lines are broad and critical. They can be utilized in drug discovery and therapeutic development, where understanding mitochondrial biogenesis and function is essential. Furthermore, these cell lines provide a framework for genetic screens, enabling the identification of novel regulatory pathways and potential targets for intervention in mitochondrial-related diseases.
What sets COX8A Gene Knockout Cell Lines apart from traditional models is their specificity and consistency in gene editing, coupled with a well-characterized genetic background. Unlike other knockout systems, our cell lines ensure predictable phenotypic expression, which reduces variability and enhances reproducibility in experimental outcomes. The targeted approach allows for precise investigations into the mechanistic pathways affected by COX8A disruption, addressing gaps that may be overlooked by more generalized models.
For researchers and clinicians focused on mitochondrial biology, the COX8A Gene Knockout Cell Lines are an invaluable asset, providing a unique opportunity to advance understanding in this critical area of research. By leveraging these state-of-the-art cell lines, users can enhance their work's relevance to human disease, ultimately driving more effective therapeutic strategies.
Our company specializes in the development of high-quality biological products, with a commitment to supporting scientific discovery through innovative tools like COX8A Gene Knockout Cell Lines.
Please note that all services are for research use only. Not intended for any clinical use.
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