Gene: CFAP45
Official Full Name: cilia and flagella associated protein 45provided by HGNC
Gene Summary: Enables AMP binding activity. Involved in establishment of left/right asymmetry and flagellated sperm motility. Located in 9+2 motile cilium; axonemal microtubule; and nucleoplasm. Implicated in visceral heterotaxy. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28798 | CFAP45 Knockout cell line (HeLa) | Human | CFAP45 | 1:3~1:6 | Negative | Online Inquiry |
KO28799 | CFAP45 Knockout cell line (HCT 116) | Human | CFAP45 | 1:2~1:4 | Negative | Online Inquiry |
KO28800 | CFAP45 Knockout cell line (A549) | Human | CFAP45 | 1:3~1:4 | Negative | Online Inquiry |
CFAP45 Gene Knockout Cell Lines represent a breakthrough tool in cellular and molecular biology, specifically engineered to enhance genetic studies involving the CFAP45 gene, known for its role in cilia function and cellular motility. These cell lines are developed using CRISPR-Cas9 technology to perform precise gene editing, resulting in the targeted knockout of the CFAP45 gene. By creating a loss-of-function model, researchers can effectively investigate the gene's physiological roles and its implications in various diseases related to ciliary dysfunction.
The primary function of CFAP45 Gene Knockout Cell Lines lies in their ability to elucidate the mechanisms by which CFAP45 influences ciliary assembly, stability, and function. This is particularly important in the context of primary ciliary dyskinesia and related pathologies, where dysfunctional cilia significantly impact cellular processes. The knockout models enable researchers to examine resultant phenotypes and dissect molecular pathways influenced by CFAP45.
In the realm of scientific research, these cell lines serve as invaluable assets for studies focusing on gene function, signaling pathways, and drug discovery. Their use can lead to significant advancements in understanding the pathophysiology of diseases linked to cilia, ultimately supporting the development of more targeted therapies.
Compared to traditional methods, such as shRNA-mediated knockdown or transgenic models, CFAP45 Gene Knockout Cell Lines offer higher specificity, efficiency, and reproducibility. Researchers benefit from accessibility to validated knockout lines that streamline experimental designs and enhance data integrity.
The unique value of CFAP45 Gene Knockout Cell Lines makes them indispensable tools for molecular biologists and genetic researchers. Their application extends to translational research, providing insights that could bridge the gap between basic science and clinical application.
Our company, with its commitment to advancing biological research, leverages cutting-edge gene editing technologies to offer high-quality, reliable, and customizable cell lines. By choosing our CFAP45 Gene Knockout Cell Lines, researchers gain access to a robust resource that will significantly enhance their investigations into gene function and disease mechanisms.
Please note that all services are for research use only. Not intended for any clinical use.
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