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CDK19 Knockout Cell Lines

Gene: CDK19

Official Full Name: cyclin dependent kinase 19provided by HGNC

Gene Summary: This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02262 CDK19 Knockout cell line (HeLa) Human CDK19 1:3~1:6 Negative Online Inquiry
KO02263 CDK19 Knockout cell line (HCT 116) Human CDK19 1:2~1:4 Negative Online Inquiry
KO02264 CDK19 Knockout cell line (HEK293) Human CDK19 1:3~1:6 Negative Online Inquiry
KO02265 CDK19 Knockout cell line (A549) Human CDK19 1:3~1:4 Negative Online Inquiry

Background

CDK19 Gene Knockout Cell Lines are specialized cellular models generated through targeted gene editing techniques, specifically designed to facilitate the study of cyclin-dependent kinase 19 (CDK19) biology. CDK19 is integral to the regulation of transcription and associated with critical cellular processes such as cell cycle progression, differentiation, and gene expression modulation. These cell lines offer researchers the advantage of studying the specific effects of the absence of CDK19, thus enabling in-depth exploration of its role in various biological contexts, including cancer and autoimmune diseases.

The key functionality of CDK19 knockout cell lines lies in their ability to mimic the phenotypic characteristics associated with CDK19 deficiency. By utilizing CRISPR-Cas9 or other gene editing methodologies, these cell lines exhibit a complete knockout of the CDK19 gene, allowing researchers to analyze changes in cell proliferation, gene transcription profiles, and response to pharmacological agents. Such insights can greatly enhance our understanding of CDK19's involvement in oncogenic pathways, providing valuable information for the development of targeted therapies.

Scientifically, CDK19 knockout cell lines hold significant importance in both research and clinical settings. They serve as an essential tool for dissecting molecular signaling pathways, contributing to the identification of potential biomarkers, and facilitating drug discovery efforts aimed at CDK19-associated diseases. Their utility extends to various applications, including high-throughput screening assays, mechanistic studies, and investigating the effects of novel compounds on CDK19-dependent pathways.

What distinguishes our CDK19 Gene Knockout Cell Lines from alternative products in the market is the precision of our gene editing techniques, which ensures a complete and reproducible knockout without unwanted off-target effects. This reliability is crucial for producing consistent data, thereby increasing the confidence researchers can place in their experimental results. Furthermore, these cell lines are readily adaptable for various experimental conditions, allowing for flexibility in diverse research setups.

In conclusion, our CDK19 Gene Knockout Cell Lines represent a valuable asset for researchers and clinicians seeking to unravel the complexities of CDK19 biology and its implication in disease states. Our expertise in generating high-quality biological products and our commitment to innovation ensure that our customers receive exceptional tools to advance their scientific endeavors and contribute to the broader field of biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

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