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BIK Knockout Cell Lines

Gene: BIK

Official Full Name: BCL2 interacting killerprovided by HGNC

Gene Summary: The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38809 BIK Knockout cell line (HCT 116) Human BIK 1:2~1:4 Negative Online Inquiry
KO38810 BIK Knockout cell line (HEK293) Human BIK 1:3~1:6 Negative Online Inquiry
KO38811 BIK Knockout cell line (A549) Human BIK 1:3~1:4 Negative Online Inquiry

Background

BIK Gene Knockout Cell Lines are genetically modified cell models designed to study the functional implications of the BIK gene in various biological processes. The BIK gene encodes a pro-apoptotic protein that plays a critical role in the regulation of programmed cell death, making these knockout models essential for elucidating the molecular mechanisms underlying apoptosis and its dysregulation in diseases such as cancer.

The primary function of BIK Gene Knockout Cell Lines is to provide researchers with a tool to examine the effects of BIK deficiency on cellular responses to stressors, drug resistance, and tumorigenesis. By utilizing CRISPR/Cas9 gene editing technology, these cell lines demonstrate a complete ablation of the BIK gene, facilitating studies on cellular signaling pathways, mitochondrial function, and the interplay between apoptosis and other cellular processes. This comprehensive approach allows for the examination of compensatory mechanisms in apoptosis regulation, offering insights into potential therapeutic targets.

The scientific importance of BIK Gene Knockout Cell Lines extends to multiple research areas, including cancer biology, neurobiology, and pharmacology. In clinical settings, understanding BIK's role can influence the development of targeted therapies that manipulate apoptotic pathways, thereby enhancing treatment efficacy for various malignancies where apoptosis is compromised.

What sets BIK Gene Knockout Cell Lines apart from alternative models is their specificity and precision achieved through advanced genome editing techniques, ensuring reliable and reproducible results. Additionally, these cell lines come with a robust validation dataset, which helps streamline experimental design and data interpretation.

These cell lines serve as invaluable resources for researchers and clinicians looking to deepen their understanding of apoptosis and its relevance in health and disease. By integrating BIK Gene Knockout Cell Lines into their studies, scientists can contribute to the forefront of therapeutic innovation and enhance their research outcomes.

Our company specializes in providing high-quality, genetically engineered cell models, reflecting our commitment to advancing biological research and clinical applications. With extensive expertise in genetic editing technologies, we ensure that our products support groundbreaking scientific discovery and application in various fields.

Please note that all services are for research use only. Not intended for any clinical use.

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