Gene: ARFGAP3
Official Full Name: ARF GTPase activating protein 3provided by HGNC
Gene Summary: The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. [provided by RefSeq, Nov 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28138 | ARFGAP3 Knockout cell line (HeLa) | Human | ARFGAP3 | 1:3~1:6 | Negative | Online Inquiry |
KO28139 | ARFGAP3 Knockout cell line (HCT 116) | Human | ARFGAP3 | 1:2~1:4 | Negative | Online Inquiry |
KO28140 | ARFGAP3 Knockout cell line (HEK293) | Human | ARFGAP3 | 1:3~1:6 | Negative | Online Inquiry |
KO28141 | ARFGAP3 Knockout cell line (A549) | Human | ARFGAP3 | 1:3~1:4 | Negative | Online Inquiry |
ARFGAP3 Gene Knockout Cell Lines are specialized cellular models in which the ARFGAP3 gene has been deliberately disrupted or 'knocked out.' This innovative product allows researchers to investigate the specific biological functions of the ARFGAP3 protein, which is known to play a crucial role in regulating vesicle trafficking and membrane dynamics. By utilizing these knockout cell lines, scientists can delve into the mechanistic pathways that involve ARFGAP3, gaining insights into its involvement in cellular processes such as Golgi organization, endocytosis, and the maintenance of cellular homeostasis.
These cell lines function by providing a controlled environment where ARFGAP3 is absent, allowing researchers to observe the resulting phenotypic changes and biochemical alterations. The absence of this gene facilitates a deeper understanding of its roles in pathological conditions, such as cancer and neurodegenerative diseases. Importantly, the ARFGAP3 Gene Knockout Cell Lines can serve as valuable tools for exploring therapeutic targets and testing potential drug candidates aimed at modulating vesicular transport and related molecular pathways.
The scientific importance of these knockout cell lines is underscored by their potential applications in both basic and applied research settings. They can be instrumental in elucidating the underlying mechanisms of disease, thereby paving the way for novel therapeutic strategies. Furthermore, these cell lines present significant advantages over genome editing techniques that may yield off-target effects, as they provide a consistent and reproducible model for studying the specific loss of function of the ARFGAP3 gene.
The unique selling point of our ARFGAP3 Gene Knockout Cell Lines lies in their ease of use and reliability, making them an indispensable resource for researchers and clinicians aiming to explore intracellular dynamics without the complications associated with traditional gene-editing methods. The robustness of these cell lines not only allows for greater reproducibility of experimental results but also enhances the overall efficiency of research endeavors.
In conclusion, our offerings in the realm of genetic research are backed by a dedicated team of experts with extensive experience in cell biology and genetic manipulation. By choosing ARFGAP3 Gene Knockout Cell Lines, you are equipping your research with cutting-edge tools that promise to unlock new avenues of discovery and therapeutic advancement.
Please note that all services are for research use only. Not intended for any clinical use.
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