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APBB1 Knockout Cell Lines

Gene: APBB1

Official Full Name: amyloid beta precursor protein binding family B member 1provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38980 APBB1 Knockout cell line (HeLa) Human APBB1 1:3~1:6 Negative Online Inquiry
KO38981 APBB1 Knockout cell line (HCT 116) Human APBB1 1:2~1:4 Negative Online Inquiry
KO38982 APBB1 Knockout cell line (HEK293) Human APBB1 1:3~1:6 Negative Online Inquiry
KO38983 APBB1 Knockout cell line (A549) Human APBB1 1:3~1:4 Negative Online Inquiry

Background

APBB1 Gene Knockout Cell Lines are specialized cellular models in which the APBB1 gene, known to play a crucial role in the modulation of signaling pathways associated with conditions such as Alzheimer's disease and other neurodegenerative disorders, has been systematically disrupted or "knocked out." This innovative product provides researchers with invaluable tools for dissecting the biological functions of the APBB1 gene and understanding its contributions to cellular processes such as synaptic signaling and cellular stress responses.

The primary function of these knockout cell lines is to allow scientists to investigate the effects of the absence of the APBB1 protein on various cellular processes. By utilizing gene editing techniques, particularly CRISPR/Cas9 or similar methodologies, these cell lines exhibit the loss of APBB1 expression, enabling comparative studies against wild-type cell lines. This aids researchers in identifying the gene's role in cellular signaling pathways and its implications in disease mechanisms, ultimately fostering advancements in targeted therapies.

The scientific importance of APBB1 Gene Knockout Cell Lines lies in their application across a myriad of research fields, particularly in neurobiology and pharmacology. They serve as vital platforms for drug discovery, toxicity testing, and elucidating gene function. Furthermore, the specificity of these lines allows clinicians and researchers to model disease states more accurately, paving the way for personalized medicine approaches.

What sets these knockout cell lines apart from existing alternatives is their precision and reproducibility, ensuring that results obtained are both reliable and relevant. Additionally, they can be easily cultured and manipulated, making them accessible for various experimental setups. The capacity to generate variant cell lines with predictable changes facilitates a streamlined research workflow, ultimately saving time and resources.

This product is particularly valuable for researchers and clinicians seeking advanced models to understand the role of APBB1 in disease mechanisms. With the potential to contribute significantly to the development of innovative therapeutic strategies, APBB1 Gene Knockout Cell Lines represent an essential addition to any cutting-edge laboratory.

With years of expertise in producing high-quality biological products, our company is committed to delivering reliable research tools that enhance scientific discovery and translate findings into clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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