Gene: VAMP2
Official Full Name: vesicle associated membrane protein 2provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00045 | VAMP2 Knockout cell line (THP-1) | Human | VAMP2 | 1:2-1:4 | Negative | Online Inquiry |
KO01315 | VAMP2 Knockout cell line (PK-15) | Pig | VAMP2 | 1:2-1:4 | Negative | Online Inquiry |
VAMP2 Gene Knockout Cell Lines are genetically modified cell lines designed to provide researchers with a powerful tool for studying the role of the VAMP2 gene in various biological processes, particularly in neurotransmitter release and synaptic function. These cell lines are created using CRISPR-Cas9 technology, which allows for precise and efficient targeting and deletion of the VAMP2 gene, resulting in a cellular model devoid of VAMP2 protein expression.
The primary function of these knockout cell lines is to facilitate experiments that examine synaptic vesicle trafficking and the mechanisms of neurotransmission. VAMP2, or Vesicle-Associated Membrane Protein 2, is critical for the fusion of neurotransmitter-containing vesicles with the presynaptic membrane, an essential step in neurotransmitter release. By studying these knockout cell lines, researchers can elucidate the pathways affected by VAMP2 deficiency and better understand synaptic disorders, paving the way for novel therapeutic strategies.
The scientific importance of VAMP2 Gene Knockout Cell Lines extends to both fundamental research and clinical applications. They are instrumental for neurobiology studies, especially in the context of neurodegenerative diseases, psychiatric disorders, and synaptic dysfunction. Researchers utilize these models to investigate the downstream effects of VAMP2 loss, contributing to a deeper understanding of disease mechanisms and potential drug targets.
What sets VAMP2 Gene Knockout Cell Lines apart from other models is their specific gene knockout feature, which provides a clean genetic background without the confounding effects often seen in partial knockdowns or overexpression systems. This specificity enhances experimental reproducibility and accuracy, attributes that are critical for high-quality research outcomes.
For researchers and clinicians seeking reliable tools for neurobiological investigations, the VAMP2 Gene Knockout Cell Lines represent a valuable asset that aids in unraveling complex pathways and advancing medical science. These cell lines leverage cutting-edge genetic engineering technologies, ensuring that users have access to the latest advancements in cellular research.
As a leader in the field of genetic modification and biological products, our company specializes in providing high-quality research tools that empower scientists at the forefront of discovery. Our commitment to excellence ensures that our VAMP2 Gene Knockout Cell Lines meet the rigorous standards necessary for impactful research outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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