Gene: USP44
Official Full Name: ubiquitin specific peptidase 44provided by HGNC
Gene Summary: The protein encoded by this gene is a protease that functions as a deubiquitinating enzyme. The encoded protein is thought to help regulate the spindle assembly checkpoint by preventing early anaphase onset. This protein specifically deubiquitinates CDC20, which stabilizes the anaphase promoting complex/cyclosome. [provided by RefSeq, Dec 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO25195 | USP44 Knockout cell line (HEK293) | Human | USP44 | 1:3~1:6 | Negative | Online Inquiry |
USP44 Gene Knockout Cell Lines are meticulously engineered cellular models that have undergone targeted gene knockout of the USP44 gene, a critical component in regulating cell cycle progression and maintaining genomic stability. These cell lines offer researchers a robust platform for investigating the biological functions of USP44, as well as its implications in various diseases, including cancer.
The primary function of USP44, a deubiquitinating enzyme, involves the modulation of protein stability through the removal of ubiquitin moieties from target proteins, thereby influencing their cellular outcomes. By utilizing USP44 Gene Knockout Cell Lines, researchers can examine the resultant phenotypic changes and disruptions in cellular pathways that occur due to the absence of USP44. This enables a deeper understanding of the gene's role in cell cycle regulation, DNA damage response, and tumorigenesis.
In the realm of scientific research, these knockout cell lines are invaluable. They provide a unique opportunity to assess the therapeutic potential of targeting USP44 in cancer treatment and to delineate the biological mechanisms at play in cell proliferation and apoptosis. Additionally, these models serve as a pivotal tool in drug discovery and development, allowing for the screening of potential compounds that may restore normal cellular functions or modify disease states that arise from USP44 dysregulation.
What distinguishes USP44 Gene Knockout Cell Lines from alternatives is their high specificity and reliability, reinforced by stringent quality control measures during production. These cell lines are genetically validated and available with comprehensive characterizations that enable researchers to achieve reproducible results consistently.
In the competitive landscape of biological research tools, these knockout models are indispensable for elucidating complex genetic interactions and advancing knowledge in therapeutic strategies. Researchers and clinicians alike will find significant value in utilizing these cell lines, enhancing their experimental approaches, and driving forward innovative discoveries in genetics and cell biology.
Our company is committed to providing cutting-edge biological products, backed by extensive research and development. With a focus on quality and scientific integrity, we deliver tools that empower researchers to achieve groundbreaking results in their investigations.
Please note that all services are for research use only. Not intended for any clinical use.
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