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TSPAN4 Knockout Cell Lines

Gene: TSPAN4

Official Full Name: tetraspanin 4provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20262 TSPAN4 Knockout cell line (HeLa) Human TSPAN4 1:3~1:6 Negative Online Inquiry
KO20263 TSPAN4 Knockout cell line (HCT 116) Human TSPAN4 1:2~1:4 Negative Online Inquiry
KO20264 TSPAN4 Knockout cell line (HEK293) Human TSPAN4 1:3~1:6 Negative Online Inquiry
KO20265 TSPAN4 Knockout cell line (A549) Human TSPAN4 1:3~1:4 Negative Online Inquiry

Background

TSPAN4 Gene Knockout Cell Lines are specialized cellular models designed for the study of the tetraspanin 4 (TSPAN4) protein, which plays a critical role in cell signaling, adhesion, and immune response regulation. These knockout cell lines are created through advanced CRISPR-Cas9 genome-editing technology, leading to the targeted disruption of the TSPAN4 gene, allowing researchers to study its biological functions without the confounding effects of the protein.

The primary function of TSPAN4 is the modulation of various cellular processes, including the organization of membrane microdomains and the facilitation of signal transduction pathways essential for effective immune cell responses. By utilizing TSPAN4 gene knockout cell lines, scientists can investigate the precise mechanisms by which TSPAN4 influences these processes, contributing to a deeper understanding of immune system dynamics and disease progression, particularly in cancer and autoimmune disorders.

The scientific importance of these cell lines is underscored by their applications in both fundamental research and clinical settings. They provide a robust platform for drug discovery, functional genomics, and the development of therapies that target TSPAN4-associated pathways. Compared to other cellular models, the TSPAN4 knockout cell lines offer specificity in targeting the gene of interest, resulting in more accurate and reliable data regarding the role of TSPAN4 in various biological contexts.

Researchers and clinicians will find exceptional value in these cell lines, as they enable the elucidation of TSPAN4’s role in health and disease, paving the way for novel therapeutic strategies. The ability to observe the effects of TSPAN4 loss on cell behavior is crucial for advancing our understanding of its pathophysiological implications.

Our company specializes in developing advanced biological products, leveraging cutting-edge technologies to provide high-quality research tools that facilitate scientific innovation. With a commitment to excellence, we ensure that our TSPAN4 Gene Knockout Cell Lines are rigorously validated and optimized for optimal performance, helping you drive your research forward effectively.

Please note that all services are for research use only. Not intended for any clinical use.

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