Home / TMX3 Knockout Cell Lines

TMX3 Knockout Cell Lines

Gene: TMX3

Official Full Name: thioredoxin related transmembrane protein 3provided by HGNC

Gene Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The canonical protein encoded by this gene has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and a C-terminal ER-retention sequence. This gene is expressed in many tissues but has its highest expression in heart and skeletal muscle. It is expressed in the retinal neuroepithelium and lens epithelium in the developing murine eye and haploinsufficiency of this gene in humans and zebrafish is associated with microphthalmia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21695 TMX3 Knockout cell line (HeLa) Human TMX3 1:3~1:6 Negative Online Inquiry
KO21696 TMX3 Knockout cell line (HCT 116) Human TMX3 1:2~1:4 Negative Online Inquiry
KO21697 TMX3 Knockout cell line (HEK293) Human TMX3 1:3~1:6 Negative Online Inquiry
KO21698 TMX3 Knockout cell line (A549) Human TMX3 1:3~1:4 Negative Online Inquiry

Background

TMX3 Gene Knockout Cell Lines are engineered cellular models specifically designed to study the functional role of the TMX3 gene, which encodes a protein involved in oxidative stress responses and cellular signaling pathways. Through precise genetic editing techniques, these cell lines have been created to completely disrupt TMX3 expression, enabling researchers to explore the gene's biological functions and its contributions to various physiological and pathological processes.

The primary mechanism of these cell lines involves the loss-of-function approach, where the TMX3 gene is inactivated, leading to altered cellular responses to oxidative stress and potential changes in signal transduction pathways. This allows scientists to comprehensively assess the implications of TMX3 knockout on cell survival, proliferation, and differentiation. Such studies are critical, as they can elucidate the gene's role in diseases such as cancer, neurodegenerative disorders, and metabolic syndromes.

In terms of scientific importance, TMX3 Gene Knockout Cell Lines have numerous applications in both research and clinical settings. They serve as valuable tools for drug discovery, as researchers can evaluate new treatments targeting oxidative stress-related pathways. Additionally, these cell lines can facilitate the understanding of gene interactions and regulatory networks, aiding in the development of gene therapies and personalized medicine.

The distinctive advantages of TMX3 Gene Knockout Cell Lines compared to traditional models lie in their precise genetic modifications, which provide more reliable and reproducible results. Unlike RNA interference methods that only temporarily reduce gene expression, these knockout cell lines offer a stable system for long-term studies, ensuring that findings are robust and can translate to in vivo applications.

For researchers and clinicians, the value of TMX3 Gene Knockout Cell Lines is evident. They not only enable the investigation of fundamental biological questions but also support translational research efforts aimed at developing innovative therapeutic strategies.

Our company specializes in cutting-edge genetic engineering technologies and offers a variety of high-quality biological products, including TMX3 Gene Knockout Cell Lines, aimed at advancing scientific discovery and improving health outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.