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SH3GL3 Knockout Cell Lines

Gene: SH3GL3

Official Full Name: SH3 domain containing GRB2 like 3, endophilin A3provided by HGNC

Gene Summary: Enables identical protein binding activity. Predicted to be involved in synaptic vesicle uncoating. Predicted to be located in acrosomal vesicle and early endosome membrane. Predicted to be part of early endosome. Predicted to be active in several cellular components, including glutamatergic synapse; postsynaptic density, intracellular component; and postsynaptic endosome. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35446 SH3GL3 Knockout cell line (HEK293) Human SH3GL3 1:3~1:6 Negative Online Inquiry

Background

SH3GL3 Gene Knockout Cell Lines are specialized cellular models designed to study the biological function and pathway interactions of the SH3GL3 gene, which plays a critical role in endocytosis and membrane trafficking. By creating knockout variants of these cell lines, researchers can effectively eliminate the expression of the SH3GL3 gene, enabling a thorough investigation of its physiological roles and potential contributions to disease mechanisms.

The primary mechanism of these knockout cell lines involves the CRISPR-Cas9 gene editing technology, which allows for precise alterations in the genomic DNA. This advancement not only ensures high fidelity in gene editing but also provides researchers with a versatile tool for elucidating the effects of SH3GL3 deletion on cellular processes such as signal transduction, cellular communication, and receptor recycling. Thus, the SH3GL3 Gene Knockout Cell Lines represent a powerful asset in dissecting the complex life cycle of cells and the dynamics of intracellular pathways.

Scientific studies leveraging these cell lines are invaluable in contexts such as cancer research, neurodegenerative disease modeling, and metabolic disorder investigations, where altered membrane dynamics can profoundly impact cell behavior. They offer insights into the pathophysiology of various conditions and could facilitate the identification of novel therapeutic targets.

Compared to alternative models, the SH3GL3 Gene Knockout Cell Lines stand out due to their specificity and the ease of gene manipulation afforded by current CRISPR technology. Additionally, these lines are validated for stable use, ensuring reproducibility and reliability in experimental results, which are critical for successful research outcomes.

For researchers and clinicians focused on cellular pathways or disease mechanisms involving SH3GL3, these knockout cell lines present a tailored solution that expedites scientific inquiry and enhances the potential for groundbreaking discoveries. Backed by our expertise in developing high-quality biological products, we are committed to providing innovative tools that support transformative research in the life sciences field.

Please note that all services are for research use only. Not intended for any clinical use.

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