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SET Knockout Cell Lines

Gene: SET

Official Full Name: SET nuclear proto-oncogeneprovided by HGNC

Gene Summary: The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01423 SET Knockout cell line(K-562) Human SET 1:3-1:5 Negative Online Inquiry

Background

SET Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to study the SET gene's function by completely knocking out its expression. This product provides a powerful tool for researchers interested in understanding the biological roles of SET in various cellular processes, including cell growth, differentiation, and response to stress. By using CRISPR/Cas9 technology, the SET Gene Knockout Cell Lines offer a precise and efficient means of gene editing, allowing for thorough investigation into how the loss of SET contributes to different pathological conditions, such as cancers and neurodegenerative diseases.

The key function of these cell lines lies in their ability to illustrate the phenotypic and molecular consequences of SET gene disruption. Researchers can utilize these lines to assess cellular viability, apoptosis, and changes in signaling pathways resulting from SET knockout. Mechanistically, the absence of this gene allows for the exploration of downstream effects on cellular machinery and gene expression profiles, enhancing our understanding of its role in disease mechanisms.

The scientific importance of SET Gene Knockout Cell Lines extends beyond basic research; they are invaluable in the development of therapeutic interventions by providing a platform for drug screening and validation. By simulating conditions in which SET is ablated, researchers can identify potential compounds that counteract the adverse effects observed in SET-related disorders, paving the way for novel treatment strategies.

One of the primary advantages of these knockout cell lines compared to alternatives, such as knockdown models, is the complete and permanent disruption of the target gene, leading to more consistent and reproducible results. Additionally, these cell lines are available in various backgrounds and conditions, catering to the diverse experimental needs of researchers.

For scientists, clinicians, and pharmaceutical developers, SET Gene Knockout Cell Lines represent a critical resource for advancing knowledge in genetics and developing innovative therapeutics. Our company, with its extensive expertise in cellular and molecular biology products, is committed to providing high-quality genetic tools like these cell lines, ensuring that our clients have access to the most effective means for exploring complex biological questions.

Please note that all services are for research use only. Not intended for any clinical use.

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