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RBBP7 Knockout Cell Lines

Gene: RBBP7

Official Full Name: RB binding protein 7, chromatin remodeling factorprovided by HGNC

Gene Summary: This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35688 RBBP7 Knockout cell line (HeLa) Human RBBP7 1:3~1:6 Negative Online Inquiry
KO35689 RBBP7 Knockout cell line (HCT 116) Human RBBP7 1:2~1:4 Negative Online Inquiry
KO35690 RBBP7 Knockout cell line (HEK293) Human RBBP7 1:3~1:6 Negative Online Inquiry
KO35691 RBBP7 Knockout cell line (A549) Human RBBP7 1:3~1:4 Negative Online Inquiry

Background

RBBP7 Gene Knockout Cell Lines are specially engineered cellular models that have undergone targeted disruption of the RBBP7 gene, a crucial regulator in various biological processes, including chromatin remodeling and gene expression modulation. These cell lines serve as an indispensable tool for researchers investigating the functional implications of RBBP7 in oncogenesis, cellular differentiation, and signal transduction pathways. By creating these knockout lines, scientists can explore the direct effects of RBBP7 depletion, facilitating the understanding of its role in pathologies such as cancer and autoimmune diseases.

The mechanism underlying the functionality of RBBP7 Gene Knockout Cell Lines revolves around the CRISPR-Cas9 or siRNA technology employed in their development, which provides precise gene editing capabilities. This results in the loss of the RBBP7 protein, allowing researchers to monitor downstream effects on cellular behavior, including gene expression profiles, cell cycle progression, and apoptosis. This targeted approach ensures that the data generated is robust and reliable, paving the way for breakthrough insights in molecular biology.

In terms of scientific importance, RBBP7 Gene Knockout Cell Lines are invaluable in both research and clinical applications, providing a platform for drug discovery and validation. Their utility extends to the study of therapeutic targets, enabling the identification of novel compounds that can restore or modulate the pathways influenced by RBBP7.

When comparing our RBBP7 Gene Knockout Cell Lines to alternative models, the key advantages include high specificity and reproducibility, as well as comprehensive support encompassing expert guidance in experimental design and troubleshooting. This makes our product particularly appealing to researchers who prioritize accuracy in their studies and clinical scientists aiming for translational applications.

The unique value of RBBP7 Gene Knockout Cell Lines lies in their ability to elucidate complex biological pathways while enabling the development of innovative therapeutic strategies. By utilizing these specialized models, researchers can significantly impact the understanding and treatment of diseases associated with RBBP7 dysregulation.

Our company prides itself on a legacy of excellence in the biotechnology sector, offering high-quality, reliable biological products backed by extensive research and development expertise. With our commitment to supporting scientific innovation, we empower researchers and clinicians alike to advance their work with confidence.

Please note that all services are for research use only. Not intended for any clinical use.

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