Gene: RAPSN
Official Full Name: receptor associated protein of the synapseprovided by HGNC
Gene Summary: This gene encodes a member of a family of proteins that are receptor associated proteins of the synapse. The encoded protein contains a conserved cAMP-dependent protein kinase phosphorylation site, and plays a critical role in clustering and anchoring nicotinic acetylcholine receptors at synaptic sites by linking the receptors to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin. Mutations in this gene may play a role in postsynaptic congenital myasthenic syndromes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01422 | RAPSN Knockout cell line(K-562) | Human | RAPSN | 1:3-1:5 | Negative | Online Inquiry |
RAPSN Gene Knockout Cell Lines are genetically modified cell lines designed to study the role of the RAPSN gene, which encodes the receptor-associated protein of the synapse. This gene is vital for neuromuscular junction function and synapse formation, and its disruption can lead to various neuromuscular disorders. These cell lines provide a powerful platform for researchers aiming to explore the underlying mechanisms involved in neuromuscular transmission and related pathologies.
The key function of RAPSN Gene Knockout Cell Lines lies in their ability to eliminate the expression of the RAPSN protein, thereby allowing scientists to investigate the resultant cellular and molecular changes. Without RAPSN, the dynamics of synaptic stability and neurotransmission are altered, providing insights into the role of this protein in cellular signaling pathways that govern muscle contraction and overall neuromuscular health. These knockout models are extensively used to study the pathology of diseases such as congenital myasthenic syndromes, offering a valuable resource for dissecting genetic factors and therapeutic targets.
From a scientific standpoint, these cell lines serve as critical tools in both research and clinical settings. They enable the exploration of potential interventions, facilitating a better understanding of treatment strategies for neuromuscular disorders. The use of RAPSN Gene Knockout models offers researchers high specificity and reproducibility, which are essential for elucidating gene function and screening pharmacological responses.
Compared to alternative models, such as wild-type cell lines or other genetic knockout systems, RAPSN Gene Knockout Cell Lines provide a unique advantage by directly addressing the specificity of the RAPSN gene's role in neuromuscular junction integrity. This specificity allows for clearer interpretations of experimental outcomes.
Researchers and clinicians will find extraordinary value in these knockout cell lines, as they not only advance fundamental knowledge but also propel the development of targeted therapies for muscle-related diseases. Our company's commitment to excellence in genetic engineering and cellular model production ensures that we provide top-tier products like RAPSN Gene Knockout Cell Lines, empowering the scientific community to make groundbreaking discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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