Gene: PRDM2
Official Full Name: PR/SET domain 2provided by HGNC
Gene Summary: This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34446 | PRDM2 Knockout cell line (HeLa) | Human | PRDM2 | 1:3~1:6 | Negative | Online Inquiry |
KO34447 | PRDM2 Knockout cell line (HCT 116) | Human | PRDM2 | 1:2~1:4 | Negative | Online Inquiry |
KO34448 | PRDM2 Knockout cell line (HEK293) | Human | PRDM2 | 1:3~1:6 | Negative | Online Inquiry |
KO34449 | PRDM2 Knockout cell line (A549) | Human | PRDM2 | 1:3~1:4 | Negative | Online Inquiry |
PRDM2 Gene Knockout Cell Lines are genetically engineered cell cultures that have been specifically modified to disrupt the expression of the PRDM2 gene, an important regulator of cell differentiation and development. This targeted gene knockout is achieved through advanced techniques such as CRISPR-Cas9 or other gene-editing technologies, which enable researchers to investigate the functional role of PRDM2 in various biological processes.
The primary function of these cell lines is to elucidate the molecular pathways regulated by PRDM2, particularly those involved in hematopoiesis, apoptosis, and the response to cellular stress. By creating specific gene knockouts, scientists can study the downstream effects of PRDM2 loss on gene expression, cellular phenotype, and overall cellular behavior. This mechanistic understanding is critical for revealing the gene's involvement in health and disease, including its implications in cancer biology and developmental disorders.
The scientific importance of PRDM2 Gene Knockout Cell Lines extends to both basic research and clinical applications. Researchers can utilize these cell lines to model diseases linked to PRDM2 dysregulation, facilitating studies that inform drug development and therapeutic strategies. Moreover, their versatility makes them suitable for high-throughput screening, enabling rapid evaluation of potential pharmacological agents targeting related pathways.
One of the distinguishing advantages of using PRDM2 Gene Knockout Cell Lines is the specificity and precision of the genetic modification, which minimizes off-target effects often associated with traditional knockdown methods like siRNA. This precision not only increases the reliability of experimental results but also enhances reproducibility. Additionally, these cell lines come with characterized backgrounds, providing a robust platform for comparative studies among different genetic contexts.
For researchers and clinicians looking to deepen their understanding of gene function and pathology, the value of PRDM2 Gene Knockout Cell Lines lies in their ability to provide clear insights into the gene's role in biological mechanisms and disease states. At [Your Company Name], we specialize in the development and production of high-quality biological products, including custom gene knockout systems, ensuring that our clients have access to the best tools for their groundbreaking research related to gene function and therapeutic development.
Please note that all services are for research use only. Not intended for any clinical use.
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